V. S. Mitrofanov

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Five patients (4 men and 1 woman) afflicted with bronchopulmonary aspergillosis (ABPA) were examined. The main criteria for the diagnosis were a high level of the total IgE, demonstration of specific IgE to Aspergillus fumigatus, positive skin tests with antigens of moldy fungi. All the 4 patients with active process, not given corticosteroids, manifested(More)
Comparative experimental study of the known antimanic drug lithium carbonate and the original compound lithium oxybutyrate that possesses a neurotropic activity similar to that of lithium carbonate has shown lithium oxybutyrate to elicit a more prolonged and more pronounced central depressant action, and a significantly less toxicity. Lithium oxybutyrate is(More)
The results obtained by a study of acute and chronic toxicity of nonachlazine--a new original coronary-active agent endowed with antianginal properties are reported. Nonachlazine has been found to have a sufficiently wide range of therapeutic action. With its repeated (for 36 days) oral introduction to rats in an effective dose of 10 mg/kg the drug does not(More)
Tests were set up on rats, guinea pigs and dogs to look into the cronic toxicity of nonachlazine, an effective antianginal agent, used for a space of 6 months in doses of 10 and 35 mg/kg, by far superior to the ones effectively employed clinically. The results of hematological, morphological and biochemical investigations bear evidence to a low toxicity of(More)
The dynamics and localization of glucose-6-phosphate dehydrogenase activity in the various structures of the brain was studied histochemically in experiments on rats after a single or repeated injection of the neuroleptic trifluoperazine and the antidepressant fluacizine. Both preparations were shown to modify the enzyme activity in many brain formations.
The influence of fluorophenazine on succinic-, citric acid-, NAD-H2-and NADP-H2-dehydrogenases in different structures of rat brain was investigated by histochemical methods. Three hours after a single subcutaneous injection of fluorophenazine (1 and 5 mg/kg) the enzymatic activity was the greatest in the limbic and the frontal regions of the cortex. The(More)