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Observational cohort studies are a powerful tool to assess the long-term outcome in chronic diseases. This study design has been utilized in local and regional outcome studies in multiple sclerosis (MS) and has yielded invaluable epidemiological information. The World Wide Web now provides an excellent opportunity for an international, collaborative cohort(More)
Multiple sclerosis (MS) is an immune-mediated neurologic disease in which acute inflammatory events early in the disease course contribute to subsequent neurologic disability. The early relapsing inflammatory phase is followed by a progressive degenerative phase in which the frequency of acute inflammatory attacks diminishes but progressive loss of(More)
studies are needed to delineate the 2 disease entities. While this article was under review, another patient with suspected CAA inflammation was reported, in whom elevated A 1– 42 and A 1– 40 autoantibodies were found in the CSF.7 In this patient, the diagnosis was made based on microhemorrhages in MRI. Histopathologic confirmation of brain inflammation was(More)
INTRODUCTION. Multiple sclerosis (MS) it is not considered any more a rare disease in Latin America. Most of the Latin American countries have reported moderate or lower prevalence data. However only very few countries have developed therapeutic guidelines. LACTRIMS prepared this consensus document with specific recommendations for the treatment of the(More)
Background Chronic cocaine use and HIV independently upregulate cellular expression of a membrane bound efflux protein, Pgp, reducing the bioavailability of HIV-protease inhibitor drugs. Pgp possesses two functionally distinct binding sites that are associated with its efflux function. It is not known if Pgp upregulation by cocaine and/or HIV infection(More)
The diagnosis of cryptococcosis is usually performed based on cultures of tissue or body fluids and isolation of the fungus, but this method may require several days. Direct microscopic examination, although rapid, is relatively insensitive. Biochemical and immunodiagnostic rapid tests are also used. However, all of these methods have limitations that may(More)
Paracoccidioidomycosis is a systemic and endemic mycosis, restricted to tropical and subtropical areas of Latin America. The infection is caused by the thermal dimorphic fungus Paracoccidioides brasiliensis and Paracoccidioides lutzii. The diagnosis of paracoccidioidomycosis is usually performed by microscopic examination, culture and immunodiagnostic tests(More)
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