V. P. Kozaruk

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Norepinephrine (NE) and epinephrine (Epi) concentrations in arterial plasma and in skin tissue were measured chromatographically before and after external cooling. Urethan-anesthetized rats were cooled either slowly (0.004-0.006 degrees C/s) or rapidly (0.03- 0.05 degrees C/s). Blood samples were drawn three times from each animal: 1) before cooling and at(More)
In rats, the effect of activation of the cold- and menthol-sensitive TRPM8 ion channel on different thermoregulatory parameters: total oxygen consumption, carbon dioxide release, respiration coefficient, constriction response of skin blood vessels, muscle activity, was studied. Activation of TRPM8 with menthol even in thermoneutral conditions produces an(More)
Animal experiments were performed to study the effects of activation of cold- and menthol-sensitive TRPM8 receptors by menthol on thermoregulatory parameters in thermoneutral conditions and on cooling. Total oxygen consumption was measured, along with expiration of carbon dioxide, the respiratory coefficient, the skin vessel constriction reaction, and(More)
Ionophoretic application of α1-and β-adrenoceptor blockers into the skin produces no effect on the parameters of thermal homeostasis under thermoneutral conditions. α1-Adrenoblocker verapamil inhibits cold shivering during fast and slow cold exposure; it elevates the temperature threshold and moderates the vasoconstrictor response during rapid cooling.(More)
We studied the role of purinergic P2X receptors in the body response to cooling. In experiments on rats, P2X receptor antagonist PPADS was administered in different modes, which resulted in changes of different characteristics of the thermoregulatory response to cold. Iontophoresis of P2X antagonist into the skin decreased the thermal thresholds of all(More)
Ionophoretic application of alpha1- and beta-adrenoceptor blockers into the skin produces no effect on the parameters of thermal homeostasis under thermoneutral conditions. alpha1-Adrenoblocker verapamil inhibits cold shivering during fast and slow cold exposure; it elevates the temperature threshold and moderates the vasoconstrictor response during rapid(More)
The modulatory effect of ionophoretic application of substance P to the skin on the formation of the cold-triggered thermal protection reactions depends on the rate of cooling. During rapid cooling substance P enhances heat production, while during slow cooling it promotes constriction of skin blood vessels aimed at reduction of heat emission.
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