V. N. Yartsev

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AIM Dependence of the melatonin-evoked potentiation of the rat tail artery neurogenic reactivity on degree of the change in the reactivity was studied. METHOD Electrical field stimulation-evoked contractile response of the juvenile rat tail artery segment under isometric conditions was recorded. 0.1 mum melatonin was administered after the change in the(More)
The effect of dynamic stretch on the reactivity of the rat tail and mesenteric artery segments was studied. Segments mounted on a myograph were stretched by a computer-controlled motorized micromanipulator. Dynamic stretch (1, 5 or 7 Hz) inhibited the artery constriction induced by noradrenaline (10 microM), 5-hydroxytryptamine (0.7 microM), or electrical(More)
The effect of melatonin on neurogenic reactivity of the juvenile rat tail artery segment was studied. The electrical field stimulation-evoked contraction of the segment decreased in the course of the experiment. Melatonin (0.1 microM) applied at different time points of the experiment produced an increase in the contraction, which directly correlated with a(More)
In experiments on isolated segments of the rat mesenteric artery, effects of changes in solution pH on the response of the segments to noradrenaline (10 microM) or electrical field stimulation (EFS) were studied. The pH 7.8 solution slightly increased (from 0.48 +/- 0.07 mN at pH 7.4 to 0.67 +/- 0.12 mN or by 41%). while the pH 7.0 and 6.6 solutions(More)
The effect of 0.03-1.0 μM noradrenaline on the neurogenic contractile response to electrical field stimulation of the juvenile rat tail artery segment in control conditions and after the solution pH decrease from 7.4 to 6.6 was studied. Acidosis were shown to inhibit this response significantly at all frequencies of stimulation used (3, 5, 10, and 40 Hz).(More)
Experiments using segments of the tail artery from young rats addressed the effects of noradrenaline on the neurogenic vasoconstrictor reactions of these segments evoked by stimulation with an electric field of frequencies 3, 5, 10, and 40 Hz in controls and after decreasing the solution pH from 7.4 to 6.6. Acidosis produced significant decreases in this(More)
The reaction to noradrenaline (NA) (10 microM) and electrical field stimulation (EFS) was studied in rat mesenteric artery segments at different magnitude of stretch and the solution pH. Alkaline solution (pH 7.8) potentiated and acidic solution (pH 7.0 or 6.6) inhibited the EFS-evoked response of segments stretched to values corresponding to arterial(More)
In vitro experiments on segments of the tail artery of young Wistar rats addressed the influence of noradrenaline (0.03–1.0 μM) on neurogenic constriction of these segments evoked by electric field stimulation in conditions of a reduction in perfusate pH from 7.4 to 6.6 or perfusate temperature from 36 to 25°C. Noradrenaline was found to potentiate(More)
Experiments on isolated segments of the tail artery from young (aged 4–6 weeks) rats addressed the effects of noradrenaline (0.01–1.0 µM) on the reactions of these segments to stimulation with an electric field in isometric conditions. These studies showed that noradrenaline increases this reaction after spontaneous or acidosis (pH 6.6)-induced decreases(More)
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