V N Saliaev

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It has been shown in rat experiments that isonarcotic concentrations of inhalation anesthetics (pentane, hexane, heptane) varied in the brain depending on the regimen of monoanesthesia. It has been demonstrated that the high content of anesthetics in the priming mixture results in a decline of the isoeffective brain concentration. Preliminary anesthesia(More)
The effect of isoniazid (200 mg/kg) on metabolism of biogenic amines in different parts of the brain was studied in acute experiments on white rats. Isoniazid was detected in all test organs one hour after the administration, with metabolism of biogenic amines changed. The level of biogenic amines is related not only to the drug distribution pattern but(More)
Under conditions prevailing in an experimental chlorocalcium arrhythmia in rats an anti-arrhythmic action of the sympatholytic-rausedyl, the gamma-adrenolytic-dihydroergo toxin, the beta-adrenolytic--obsidan, the M-cholinolytics--atropine and benactyzine was ascertained. The N-cholinolytics tropacin and hexamethonium had no effect on the parameters and the(More)
The indices of central hemodynamics and myocardial contractility were studied by poly- and mechanocardiography in 25 patients with stage I-IIA circulatory insufficiency prior to and after treatment with 1-dioxyphenlalanine. The content of lactic and pyruvic acids in the blood and erythrocyte permeability to 32P were determined at the same time. The activity(More)
Distribution of ftorotan in the brain structures (hemispheres, thalamus, cerebellum, limbic structures) and blood, and permeability of the blood brain barrier of the listed brain structures were studied by gas chromatography in postnatal ontogenesis (7, 17, 30, 60 and 90 days) of white rats during three stages of anesthesia -- initial, "surgical" and final(More)
The anti-arrhythmic activity of protopin, quinidine and novocainamide infused intravenously as a preventive and relieving measure was studied in acute experiments on rats with calcium chloride and aconitic arrhythmia. In myocardial fibrillation induced by calcium chloride the contents in the rat heart of adrenalin, noradrenaline, dopa and dopamine were(More)
It has been discovered in experiments on rats with traumatic paralysis of the sciatic nerve that a methacrylic acid derivative, beta-aminoethylmethacrylate (AEM), displays marked neurotropic, particularly strychnine-like activity. Using visual, electrophysiological and biochemical research methods it has been demonstrated that the substance has a(More)