V. N. Mitin

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In this study efficacy of antineoplastic action of gadolinium NCT and boron NCT in cases of canine melanoma and osteosarcoma was compared. Canine spontaneous tumors, such as melanoma and osteosarcoma, have clinical common features with human malignancies, so these tumors in dogs can be considered as clinical model of human melanoma and osteosarcoma. The(More)
The paper discusses results of the assay of androgen receptors in the cytosol fraction of osteogenic sarcoma (primary tumor and metastases) in 17 dogs. In some cases, osteogenic sarcoma and its metastases revealed androgen receptors in a wide range of concentrations (15-340 fmol/mg protein). Metastatic tumors appeared to have the highest receptor levels.(More)
Distraction osteogenesis by Ilizarov's method is becoming popular for limb saving surgery today. In this article we report a case of osteosarcoma recurrence after using bone distraction in a dog with osteogenic sarcoma. This case suggests that stimulation of osteogenesis by bone distraction promotes tumor recurrence and metastases in osteosarcoma. We(More)
A case is reported of osteosarcoma arising in a dog after the fracture of the femur. The tumor was diagnosed 6 years after the trauma. We suppose that the cause of malignant transformation in this case was a permanent mechanical trauma, restructuration and regeneration of the bone. This mechanism, possibly, also may take place in the genesis of primary(More)
Transfusion of allogenic bone marrow to prevent metastasizing of osteogenic sarcoma was studied as an alternative to aggressive chemotherapy in cases when it is impossible to preserve the limb. The study was carried out on 62 dogs with spontaneous osteogenic sarcoma. A single preoperative transfusion of allogenic bone marrow was carried out in 42 dogs one(More)
The cell tumorigenic ability and the cell clonogenicity in semi-solid medium of highly radioresistant variant cell line, PIC-20 (the progeny of djungarian hamster fibroblast cell line DX-TK- surviving acute exposure to 20 Gy of gamma-irradiation), were examined. In the absence of additional radiation, no differences between tested features of non-irradiated(More)
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