V. N. Kroutko

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The evolutionary theory of aging predicts that the equilibrium gene frequency for deleterious mutations should increase with age at onset of mutation action because of weaker (postponed) selection against later-acting mutations. According to this mutation accumulation hypothesis, one would expect the genetic variability for survival (additive genetic(More)
Since paternal age at reproduction is considered to be the main factor determining human spontaneous mutation rate (Crow, J. (1993) Environ. Mol. Mutagenesis, 21, 122-129), the effect of paternal age on human longevity was studied on 8,518 adult persons (at age 30 and above) from European aristocratic families with well-known genealogy. The daughters born(More)
Based on an analysis of current literature, this work deals with mechanisms of intoxication and detoxication during the aging process, as well as prospects for applying enterosorption as a detoxication technique for prolonging life. Enterosorption belongs to scientific field in which Russian researchers are ahead of others. Therefore, the most interesting(More)
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