V. M. Okujava

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A highly-sensitive microcolumn HPLC method for the simultaneous determination of carbamazepine and carbamazepine-10,11-epoxide in human serum and saliva is described. The method was successfully employed for the study of pharmacokinetics of carbamazepine in humans. After oral administration of 100 and 200 mg of carbamazepine to a volunteer, multiple peaks(More)
Hyperpolarizing afterpotentials of penicillin-induced (local application) paroxysmal depolarizing shifts (PDS) in neurons of the sensorimotor cortex of the cat were studied. The pattern of membrane conductance changes within different segments of hyperpolarization and the data on the role of various ion currents in its generation allow us to conclude that(More)
In most studies of epileptic activity, excitatory phenomena always attracted special interest because epileptic seizures and their experimental models, as well as interictal paroxysmal events, usual ly seemed to correlate with abnormal excitation of various cerebral s t ructures [1-3]. At the same time, the role of the s y n a p t i c inh ib i to ry process(More)
The interaction of carbamazepine and chlorpromazine in rabbits has been studied. The drugs were administrated as single oral doses (200 mg of each drug). The sequence of administration of the drugs was varied. It has been established that by simultaneous administration these drugs decrease absorption of each other in plasma. This may be explained by(More)
The interaction of carbamazepine and phenobarbital in rabbits was investigated. The drugs were administered to the rabbit orally as a single dose. By simultaneous administration the sequence of drugs was varied, with an interval between doses of 15 min. The doses of carbamazepine and phenobarbital were 100 and 25 mg, respectively. It was established that(More)
A normal-phase microcolumn HPLC method is proposed for the quantitative determination of the most frequently used antiepileptic drugs and some compounds developed recently. The main advantage of this method, in comparison with other micro-scale HPLC techniques for antiepileptic drugs, is that it is used under isocratic conditions at room temperature (22(More)
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