V. M. Klimenko

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Impairments to cognitive functions in in children and adults often result from various pathologies occurring during the prenatal period and early postnatal period of development (birth traumas, hypoxia, infectious diseases). The present study identified impaired learning in a Morris water maze in adult rats given interleukin-1β during the third week of(More)
Impairments to cognitive functions in children and adolescents often result from a variety of types of prenatal pathology (birth traumas, ischemia, hypoxia, and allergic and infectious diseases in early life) accompanied by high levels of production of the proinflammatory cytokine interleukin-1β. The studies reported here identified impairments to the(More)
A number of studies showed association of mental status with heart rate variability. This work discovered a feature of frequency structure of heart rate variability that is associated with mental readiness. In three independent groups of 64, 39, and 19 volunteers by the factor analysis of heart rate periodograms, it has been discovered that there are at(More)
The ability of the brain serotonergic system to mediate the effects of interleukin-1beta (IL-1beta) was investigated. Intracerebroventricular administration of IL-1beta induced a significant pyrogenic reaction, depression in social behaviour, loss of body weight and reduced food intake in rats. Pre-treatment with p-chlorphenylalanine, an inhibitor of(More)
ческих наблюдений. The article describes the main areas of research IP Pavlov in the field of neurophysiology, and traced its development in modern neurosciences.
Neuropeptide galanin produces a antipyretic effect in experimental pyrogenic reaction induced by intraperitoneal injection of lipopolysaccharide. Central intracerebroventricular injection of 100 ng galanin significantly attenuated, but did not completely abolish fever. Central galanin injection potentiated endotoxin-induced activation of the noradrenergic(More)
The regenerative capacity of the Central Nervous System (CNS) is a key factor implicated in the pathogenesis of neurodegenerative diseases. In the present study, the regenerative capacity of the CNS is considered using one of the markers of regeneration, Growth Associated Protein-43 (GAP-43) and its proteolytic fragment GAP-43-3 in the Experimental(More)
The effects of intracisternal administration of insulin at doses of 2.5, 25, 50, and 200 ng on the behavior of rats in an open field test and elevated plus maze were studied at 45 min, 24 h, and nine days after single doses. On day 1, doses of 2.5 and 25 ng increased the probability of orientational-investigative behavior and locomotion in the open field,(More)