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Recent studies suggest that activation of the atrial muscarinic K+ current by acetylcholine (ACh) involves an ATP-dependent process that is then inhibited by a cytosolic protein to result in the rapid desensitization. To obtain further evidence in support of such a dually regulated process, we studied the properties of GIRK1 and GIRK4, which, when(More)
Unisite ATPase kinetic constants were measured for wild-type yeast Saccharomyces cerevisiae F1-ATPase and F1-ATPase with the Thr197-->Ser mutation in the beta subunit. Under unisite conditions, the concentration of ATP is greater than that of the enzyme, ATP hydrolysis is slow and the affinity of the enzyme for ATP and ADP is high. The Thr197-->Ser mutation(More)
Induction of chromosome aberrations in G0 lymphocytes of peripheral human blood exposed to 235U and d(50)+Be neutron radiation was studied. Dose--effect relationships for different types of chromosome aberrations were analyzed. Linear dependence of the effect was established for the studied neutron radiation, except for the yield of dicentrics exposed to(More)
A contribution of gamma-radiation to a total dose absorbed in the radiation field formed during 50 MeV proton bombardment of a beryllium target has been determined. A study was made of the biological effectiveness of action of mixed gamma/neutron-radiation on albino mongrel and inbred (C57 black) female mice.
Certain alterations have been revealed in the postnatal ontogenesis parameters of albino mongrel rats and their descendants constantly kept within the thirty-kilometer zone of the Chernobyl A.P.S. Structural disturbances have been found in bone marrow cell chromosomes.
In studying the bone marrow cell ultrastructure in male rats (F0-F2 generations) aged 3 months, which were brought up within the thirty kilometer Chernobyl A.P.S. disaster area, considerable submicroscopic changes have been revealed in the cells at all stages of maturation, including undifferentiated blasts and mature forms of cells of the neutrophilic,(More)
The permanent action of small doses of low-intensity radiation on the immune status of 2.5-3.5 month CC57W mice has been investigated. Total doses of internal and external irradiation were about few cGy. The permanent action of low-level radiation on the experimental animals of the first and fourth generations was shown to change spleen and lymph nodes(More)
The rate of the total absorbed dose within a radiation field produced by the reaction of accelerated (up to 50 MeV) deuterons with a thick beryllium target has been determined and the uniformity of the dose field studied. LD50/30 for C57Bl mice has been evaluated in a mixed gamma/neutron field.