V. L. D'yakov

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Polyethyleneimine (PEI, 50 kDa) and polymethacrylic acid (PMA, 200 kDa) were shown to inhibit the lysis of sheep erythrocytes induced by the guinea pig complement. They twofold suppress the hemolysis at the concentrations of 0.47 and 0.89 μg/ml, respectively. The inhibitory effect on the binding of the C1q subunit of human complement to the sensitized sheep(More)
The appearance of multiple drug resistance (MDR) in tumors during a course of chemotherapy narrows the scope for the use of cytostatics. This phenomenon is known for several different tumor cells. It has been shown that MDR is connected with the development of the unique ability of the tumor cells to reject toxic substances due to the formation of new(More)
The reaction of chymotrypsin with a number of modified analogs of the specific inhibitor of chymotrypsin L-1-tosylamido-2-phenylethyl chloromethyl ketone has been studied; the compounds investigated were D-1-tosylamido-2-phenethyl chloromethyl ketone, phenethyl chloromethyl ketone (PECK), and benzylethyl chloromethyl ketone (BCMK). It has been shown that(More)
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