V. L. Chubykin

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The role of homologue pairing and chromocentral association of chromosomes in recombination and segregation during cell division is discussed. Peculiarities of mitotic and meiotic chromosome pairing in Drosophila males and females are considered. On the basis of our own and published data, the presence and localization of sites of homologue pairing(More)
The chromocenter is known as an integration of chromosome precentromeric heterochromatin regions. The squash technique was used for light microscopic analysis of chromocentral structures in Drosophila oocytes and trophocytes. The females displayed different structures of autosome 2. The precentromeric regions of autosome heterochromatin (chromocentral(More)
The genetic screen for the meiotic mutations showing chromosome non-disjunction in mosaic clones of female germ line generated by FLP-FRT mediated mitotic recombination was performed. The sterile meiotic mutation ff16 (69D1-70A2) was found among the mutants obtained. In the male germ line the mutation showed lack of meiosis 1 cytokinesis and other meiotic(More)
The evidence supporting universal significance of physical links between pericentromeric regions of homologous chromosomes for their bipolar orientation during the first meiotic division is discussed. The pericentromeric chiasmata between homologs or (in the absence of the latter) chromocentric links between nonhomologs, which are preserved until(More)
Homolog pairing, chromosome morphology, and chromosome disjunction in the first meiotic division were studied in the oocytes of c(3)G/c(3)G female Drosophila melanogaster at developmental stages 3-4 and 14. It was found that homologs were completely or partly paired in some cells (about 20% in either case). The lengths of chromosomes in +/+, +/c(3)G, and(More)
Features of main recombination stages in eukaryotes-homologous pairing, cleavage of specific DNA sites and their delayed repair, formation of heteroduplexes (X-structures), resolution of X-structures by crossing over or gene conversion--and various factors affecting these stages and changing the number of X-structures and frequency of crossing-over are(More)
The structure of chromocenter and pairing of homologs in Drosophila oocytes with different X-chromosome inversions (sc7, sc9, BM1, y4, sc4sc8), and acrocentric compound C(1)DX were studied. Disturbances of chromosome pairing in compound C(1)DX, inversion of heterozygotes and some homozygotes (BM1, sc4sc8) were observed. Besides, disturbances of(More)
Two laboratory strains of Drosophila melanogaster carrying autosome 3 with a meiotic mutation c(3)G, that is maintained since 1985 in various balancer chromosomes, were used to study progeny survival. The conditions of maintenance of these strains and the effect of c(3)G mutation completely suppress pairing and crossing over in autosome 3. In addition,(More)