V. K. Khugaeva

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The effect of bradykinin on microcirculation was studied in vivo on the rat mesentery. Bradykinin (0.01--10 micrograms) caused three types of reactions of arterioles and venules (constriction, dilatation, no changes in the diameter) in relation to the dose used. Preliminary application of noradrenaline changed the sensitivity of microvessels to bradykinin(More)
The response of the blood flow and arterioles (the change in their diameter) in the rat mesentery to application of histamine (100–500 μg) and adrenalin (1–10 μg) was studied in vivo. The sensitivity of the microvessels 10–30 μ in diameter to the action of these substances was reduced in hypertension.
The dynamics of the capillary hematocrit in 4-5-, 7- and 11-week rats involved its reduction with ageing from 0.17 l/l in 4-5-week rats to 0.10 l/l in 7- and 11-week ones in spite of considerable variability in each animal group. The reduction of the hematocrit seems to be due to the growth of capillary net in mesentery.
A modifed technique that allows in vivo study microcirculation in the rat lungs using a special camera. Feature of the method is stable fixation of lung tissue, which prevents its displacement during the study. Imaged surface of the lung tissue (alveoli with surrounding them on all sides capillaries).
In the dynamics of the experimental renal and hormonal hypertension in rats tracked change parameters such as blood pressure (BP), angiogenesis in microvessels of mesentery in small intestine, the number of mast cells (MC) surrounding microvessels. The same increase in BP there were qualitative and quantitative differences of angiogenesis in microvessels of(More)
Intravital studies of microcirculation and packed-cell volume in microvessels of rat mesentery demonstrated changes in the direction of the flow and packed-cell volume in the course of 17 minutes' ischemia caused by the occlusion of the afferent arteriole. Deficient inflow to the ischemized region is at first compensated for by the inflow from other(More)
Reactivity of mesenteric arterioles 10–30 μ in diameter to application of histamine (100–500 μg) adrenalin, and noradrenalin (1–10 μg) was studied in rats with experimental renal and hormonal hypertension. The sensitivity of the microvessels to the vasoactive substances was shown to vary with the stage of development of experimental hypertension.