V. Jendruchová

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Time sequence study was performed to characterize the effects of diabetes mellitus type 1 on properties of the Na, K-ATPase in cerebral cortex derived from normal and streptozotocin (STZ)-diabetic rats of both genders. The samples were excised at varying time intervals of diabetes induced by STZ (65 mg kg−1) for 8 days, and 8 and 16 weeks. Expression of(More)
The present study was oriented to gender specificity of Na,K-ATPase in cerebellum, the crucial enzyme maintaining the intracellular homeostasis of Na ions in healthy and diabetic Wistar rats. The effects of diabetes on properties of the Na,K-ATPase in cerebellum derived from normal and streptozotocin (STZ)-diabetic rats of both genders were investigated.(More)
OBJECTIVE Familial hyperkalaemic hypertension (FHHt) also known as Gordon syndrome is a rare form of hypertension. DESIGN AND METHOD In 2001, WNK1 and WNK4, have been identified as responsible for this syndrome, regulating the ion transport in the kidney. In 2012, an American laboratory as well as ours, have identified two other genes, KLHL3 and CUL3 as(More)
Previous studies showed that adverse effect of ionizing radiation on the cardiovascular system is beside other factors mostly mediated by reactive oxygen and nitrogen species, which deplete antioxidant stores. One of the structures highly sensitive to radicals is the Na,K-ATPase the main system responsible for extrusion of superfluous Na+ out of the cell(More)
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