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The benzimidazole carbamates are important broad-spectrum drugs for the control of helminth parasites in mammals. David Gottschall, Vassilios Theodorides and Richard Wang explain that the metabolism of these compounds depends heavily on the substituent present on carbon-5 of the benzimidazole nucleus and involves a wide variety of reactions. Work in vitro… (More)
Previously, we have described an in vitro model of granulomatous hypersensitivity around Schistosoma mansoni eggs in both the murine model of schistosomiasis and in human schistosomiasis. These studies describe a new model of in vitro granuloma formation that complexes soluble egg antigen from S. mansoni eggs, a partially purified protein derivative of… (More)
Albendazole, a benzimadazole-carbamate anthelmintic, has been shown to effectively cause destruction of the metacestodes of Taenia saginata in calves.
Albendazole in drench formulation was administered to calves 16 weeks after infection with 400 metacercariae of Fasciola hepatica. In separate experiments, albendazole at dose levels of 10 or 15 mg/kg reduced the fluke burden by 92.84 per cent and 95.0 per cent, respectively. In another experiment, a dose level of 7.5 mg/kg given once, twice with a two-week… (More)