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Psoriasis was used as a model to analyze the pathogenetic pathways of immune-mediated inflammatory diseases, and the results of bioinformatic, molecular-genetic and proteomic studies are provided. Cell mechanisms, common for the pathogenesis of psoriasis, as well as Crohn's disease, are identified. New approaches for immune-mediated diseases are discussed.
In experiments on rats, we studied the effects of experimental hyperthyroidism (subcutaneous injections of L-thyroxine, 50 μg/kg·day during 7 days) and hypercorticoidism (daily i.p. injections of hydrocortisone, 3 mg/kg·day during 30 days) on parameters of the М responses of the m. tibialis anterior after stimulation of the n. peroneus by single stimuli and(More)
Three-dimensional models of skin and epidermis imitate the structure of real tissues and provide accurate information about certain skin conditions, such as psoriasis. A three-dimensional model of mouse epidermis was generated from the epidermal keratinocytes of newborn mice and treated with cytokines. The aim of this study was to evaluate this model as an(More)
In experiments on rats, we studied the effects of experimental hyperthyroidism (subcutaneous injections of L-thyroxine, 50 μg/kg·day during 7 days) and hypercorticoidism (daily i.p. injections of hydrocortisone, 3 mg/kg·day during 30 days) on parameters of the М responses of the m. tibialis anterior after stimulation of the n. peroneus by single stimuli and(More)
In white rats both adapted and unadapted to cold, the RQ dynamics during cold exposure, noradrenaline and ganglion blocking agent administration, were studied. The adapted animals' RQ in thermoneutral conditions was shown to be a little higher than in the control rats; 0.5 mg/kg noradrenaline injections induced a clear RQ decrease in the former and did not(More)
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