V I Sharapov

We don’t have enough information about this author to calculate their statistics. If you think this is an error let us know.
Learn More
The experiments in rats showed the changes in the fatty acids composition of lipids of hepatic microsomal membranes and lipids of blood plasma after acute hypobaric hypoxia to depend on individual resistance of animals to oxygen deficiency. In highly resistant rats the content of unsaturated fatty acids and lipid peroxidation activity in blood plasma(More)
We studied antipyrine metabolism in rats with different resistance to hypoxia during adaptation to cold stress. Changes in the concentrations of some antipyrine metabolites at low temperature were associated with individual resistance to hypoxia. In low-resistant rats, antipyrine metabolism was suppressed from day 5 of cold exposure to day 3 of the recovery(More)
In experiments on rats it was shown that the liver ischemia produces a decrease of the maximal rate of amidopyrine and aniline hydroxylation in microsomes on the 3rd day of the postischemic period. A considerable depth of aniline metabolism inhibition following hepatic ischemia is related to reduced affinity of cytochrome P-450 to substrates of type II. On(More)
171 iron-deficient painters and 20 subjects with chronic intoxication with aromatic hydrocarbons were studied in a large aircraft construction factory. After correlative analysis of iron metabolism, ferritin, erythrocytes, diameter and perimeter of reticulocytes, length of service three types of iron-deficiency were identified: typical, with evident(More)
The experiments on rats have shown that coronary artery ligation reduces the content of microsomal cytochromes P-450 and b5 and causes amidopyrine-N-demethylation and aniline-p-hydroxylation disturbances that persist throughout a 3-week period of myocardial infarction. The investigation of spontaneous lipid peroxidation of microsomal membranes in myocardial(More)
The character of changes in the metabolism of antipyrine, etoxy-, methoxy- and pentoxyresurphin after total reversible ischemia of the liver was studied in rats. In animals highly resistant to hypoxia the metabolism of xenobiotics specific to cytochromes P-450 IA1, IA2, and IIB1 was inhibited; in subjects with low resistance to hypoxia only P-450 and IA1(More)
Rat experiments have shown preliminary administration of phenobarbital and zixoryn (before ischemia) fails to prevent the hepatic monoxygenase system from ischemic lesion, followed by profound destructive changes in the liver, though the functional activity of the microsomal system remained high. Phenobarbital and zixoryn induction of monooxygenases in the(More)
It was found in experiments on the in vitro model of rat liver ischemia that ischemia initiates membrane lipid peroxidation and proteolysis leading to damage of monooxygenase enzyme systems of microsomes. Preventive administration of alpha-tocopherol, lidocaine, contrykal and their combinations revealed the optimal protective effect of the combined(More)