V I Sanotskiĭ

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We studied the functional role of individual subtypes of muscarinic cholinoceptors in the pathogenesis of neuroleptic parkinsonism in rats. Blockade of M4 receptors prevented the development of extrapyramidal disorders, which was abolished by simultaneous blockade of M2 receptors. The data suggest that various subtypes of muscarinic receptors are involved(More)
The effects of reversible (galanthamine, eserine) and irreversible organophosphate (armine) cholinesterase inhibitors on excitable muscle fibre membrane of the frog involved elongation of the rise and the half-decay time of the AP (galanthamine and eserine), the critical level of depolarization being shifted to a more negative value. Armine decreased the(More)
We studied the relationship between the efficiency of muscarinic receptor antagonists in preventing haloperidol-induced catatonia and their activity in tests for the interaction of ligands with various subtypes of muscarinic receptors (M1-M4) in rats. Mathematical modeling showed that affinity of the ligand for M4 receptors positively affects its ability to(More)
Alterations induced by the cholinesterase inhibitor armin (5.10(-7) g/ml) in the ultrastructure of motor nerve endings of the rat phrenic diaphragmal preparations at rest or electric stimulation of the nerve were studied. It was shown that armin at rest induced ultrastructural lesions in the endings similar to those in the control preparations during nerve(More)
Presynaptic effect of compound application of the cholinesterase (ChE) inhibitors of the reversible (galanthamine) and the irreversible (armin) after galanthamine pretreatment has been studied on the neuromuscular transmission at the rat diaphragm. The experiment conditions were regarded as a model of the preventive action of the reversible ChE inhibitors(More)
Quantitative assessment of selective blockade of M4-subtype muscarinic receptors was performed by the number of pilocarpine-induced movements of lower jaw in rats. Three antagonists (atropine, cyclodol, and glipin) were used in the experiments. Glipin produced the most potent blockade of M4 receptors in the whole organism compared to other test antagonist.
Study of the action of armin on the nodes of Ranvier in isolated nerve fibers of the frog has demonstrated that armin at concentrations over 4 X 10(-7) M produces the growth of the input resistance of the nodes of Ranvier at the expense of the decreased leakage conduction. At concentrations of 4 X 10(-6) and 4 X 10(-5) armin leads to a shift of the firing(More)
Miniature end-plate currents (MEPC) in rat diaphragm were studied with voltage-clamp technique when synaptic acetylcholinesterase (AChE) was inhibited with different concentrations of galanthamine. The MEPC amplitude and time course were increased progressively with galanthamine concentrations in the range of 3.16 X 10(-8) - 10(-6) g/ml. The decay of MEPC(More)
Actions of the two cholinesterase inhibitors: armin and galanthaamine on the neuromuscular transmission and on the spontaneous and evoked acetylcholine release were studied in the rat diaphragm. High concentrations (greater than or equal to 10(-6) g/ml) of these agents exhausted the available transmitter store which decreased the quantum content of e. p. p.(More)
The action of armin, an organophosphorus inhibitor of cholinesterases, on synaptic transmission parameters was studied by means of intracellular registration of end plate potentials and currents (EPP and EPC) in the frog. On 10-minute exposure the increase in the temporary parameters became manifest provided the drug was administered at a concentration of(More)