V. I. Rakhmanova

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Using optical dissector methodology, a morphometric study of numerical density of oligodendroglial cells in layer VI and in adjacent white matter of Broadmann area 10 has been conducted in 23 postmortem brains of schizophrenics and 20 matched controls. Comparing to controls, a significant reduction of numerical density of oligodendroglial cells was found in(More)
A qualitative and quantitative electron microscopic study of oligodendroglial cells was performed in autoptic (4-6.5 hours after death) prefrontal area 10 in 16 cases of schizophrenia, 6 cases of bipolar affective disorder and 16 normal controls, as well as in the caudate nucleus in same schizophrenic and control cases. The signs of reactive, regressive,(More)
slightly. In arterioles it dropped only 8% on average. The hemodynamic response of individual arterioles was heterogeneous, probably due to the mesenteric angioarchitectonics. The polymer lowered blood pressure in radial arteries by 19.4 and 18.4% (in comparison with the period before and after administrat ion of adenosine, respectively); AP dropped by(More)
Acetylcholinesterase activity was quantitatively evaluated by cytochemical method in brain structures (layers III and V of the sensorimotor cortex, caudate nucleus, nucleus accumbens, hippocampus CA3 field) of August and Wistar rats demonstrating high and low motor activity in the open fi eld test. In August rats, acetylcholinesterase activity in the(More)
Monocyte activation is consistently reported in patients with schizophrenia (SZ). We aimed to study the ultrastructure of monocytes and monocyte production of IL-1β in drug-free patients with SZ and controls. Monocytes from young (18–30 y.o.) healthy and SZ men in relapse were studied. Electron microscopy and morphometry were applied to estimate areas of(More)
Differences have been found in responses of the brain formations studied by some protein metabolic parameters. They manifest themselves both between the neurons of cortical and subcortical structures and between those of various morphofunctional types and affect the corrective action of delta-sleep peptide.
Monoamine oxidase activity was quantitatively assessed by cytochemical method in brain structures (layers III and V of the sensorimotor cortex, caudate nucleus, nucleus accumbens, hippocampal CA3 field) of rats of August line and Wistar population with high and low locomotor activity in the open fi eld test. Monoamine oxidase activity (substrate tryptamine)(More)
Electron microscopic morphometric study of postmortem prefrontal cortex (area 10) and visual cortex (area 17) was performed to estimate the numeric density (Nv) of synapses in layers I and II, neurons in layer II and the number of synapses per neuron in layer II in 20 cases of chronic schizophrenia and 16 healthy controls using stereological physical(More)
OBJECTIVE Neuroimaging studies showed abnormalities in frontal white matter (WM) in schizophrenia that were associated with clinical symptoms. Previously, we reported ultrastructural alterations of myelinated fibers and reduction in the numerical density of oligodendrocytes in BA 10 WM in patients with schizophrenia. We aimed to perform a qualitative and(More)
To have objective quantitative characterization of the structural features of alcoholic encephalopathy after abstinence, a morphometric analysis was made of the changes in nerve and glial cells of the sensorimotor brain cortex of rats 7 days after the discontinuation of long alcoholization of the animals. A significant decrease of the density and size of(More)