V. I. Linenko

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, N N Ie-d I Ia-j Ia: R = NH~, R' = Ph; Ib: R-----NH=, R' -4-CHsOC6H4; Ic: R = NH~, R' = 4-NOsCeH,; Id: R = N H 2 , R ' =4 Br C eH , ; IIa: R = H , R ' = B u t ; II15: R = H , R = P h ; I lc: R = = H , R':--4-CH3C~H,; Ild: R----H, R'-----4-O=NC6Hj I le : R = H , R '=4-BrCeH~; IIf: R = H , R'-----cc-thienvj~ I Ig : R=NH=, R ' = P h ; I I h : R = N H 2 ,(More)
We synthesized for the first time imidazo[4,5-g]indolizines from the 5-acylmethyl salts of 4-alkyl derivatives of imidazo[4,5-c]pyridine [5], and some of its styryl derivatives exhibited in the tests high antifungal and antibacterial activity [6, 7]. The aim of the present work was to find among the benzylidene derivatives of imidazo[4,5-g]indolizine,(More)
In the present communication the reaction of some mercaptoazoles with propargyl bromide has been studied. It was shown previously [1-5] that benzimidazoline-2-thione with propargyl bromide forms 2-(prop-2'-ynyl)mercaptobenzimidazole which is of interest for the synthesis of 3-methylthiazolo[3.2-a]benzimidazole or for studying 3,3-sigmatropic rearrangements.(More)
The prepara t ion of some 7-acylmethyl-8-chlorotheophyllines and the analogous bromo derivatives has been described in the l i tera ture [2-5]~ By the react ion of these compounds with p r imary and secondary amines we have synthesized 7-acylmethyl-8-alkylamino(arylamino, dialkylamino)-theophyllines, and f rom the lat ter the corresponding hydrazones ,(More)
Quinazolin-4(3H)-ones can be alkylated with ~-halocarbonyl compounds at N3 [3, 5, 6]. In our case 2-chloroquinazolin-4(3H)-one (I) easily reacts with ~-haloketones in methanol solution in the presence of an equimolecular quantity of sodium methylate forming 3-acylalkyl2-chloroquinazolin-4(3H)-ones (III-VII, Table i). As a result of the presence of a labile(More)