V. I. López-Ríos

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The classic theory of optimal experimental designs assumes that the errors of the model are independent and have a normal distribution with constant variance. However, the assumption of homogeneity of variance is not always satisfied. For example when the variability of the response is a function of the mean, it is probably that a heterogeneity model be(More)
Two nested pharmacokinetic models are considered in this work. Several observations are taken on the same subject so they are correlated. The covariance function assumed is an exponential covariance function. Optimal exact designs are computed with different criteria, both for discriminating between models and estimating parameters. Compound criteria to(More)
This paper evaluates a new methodology for calibration of hydrodynamic models based on the theory of statistical design of experiments. An Eulerian-Eulerian hydrodynamic homogeneous model, integrated by the commercial software CFX Ansys Inc., is used to perform the numerical experiments. For the screening step, the fractional factorial experimental design(More)
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