V. I. Arkhipov

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Cognitive processes and functional state of mitochondria in brain structures of Wistar rats were studied after intrahippocampal injection of kainic acid, an agonist of glutamate receptors. A single administration of 0.25 microg kainic acid into the dorsal part of the left and right hippocampi affected task retrieval and decreased inhibition of unrewarded(More)
The phenomenon of dissociated memory retrieval is observed when some influences (for example, pharmacological) on the brain result in specific changes of long-term memory. The purpose of present paper is to reveal possibilities of the phenomenon for study of long-term memory retrieval. Pharmacologically-induced dissociated states could be identified when(More)
The effects of the neurotoxin kainic acid on a food-producing habit were studied in Wistar rats in an experimental chamber. Single doses of kainic acid at a subconvulsive dose (8 mg/kg, i.p.) were found to impair the habit, onset of impairment being delayed by several weeks rather than immediate. Conversely, administration of the neurotoxin at the(More)
The stage of retrieving long-term memory traces is discussed; studies of this stage can be performed using the phenomenon of dissociated brain states. These states arise in response to various external influences and are accompanied by selective, reversible derangements of retrieval processes without alteration of the mechanisms involved in perceiving and(More)
In vitro protein phosphorylation of synaptic membranes isolated from neocortex and hippocampus of ground squirrels was studied. Three functional states of animals were investigated: torpid, awakened and active normothermic. Phosphorylation of a protein with a mol. wt of 53 kDa was independent on the functional state of the animals. Incorporation of 32P into(More)
The expression of mitochondrial protein UCP2 and cytochrome C-oxidase subunit III genes in the hippocampus and prefrontal cortex was evaluated by real-time PCR 3 and 7 days after microinjection of kainic acid into the dorsal hippocampus. In contrast to cytochrome C-oxidase subunit III mRNA, the level of UCP2 mRNA in the hippocampus increased 1 week after(More)
We studied the possibility of conditioning of food-procuring response in animals after impairment of the dorsal hippocampal region with kainic acid. Histological studies of brain sections showed that the greater part of dorsal hippocampal CA3 pyramidal neurons were lyzed in 2 weeks after kainic acid microinjection into the hippocampus. Morphological signs(More)
AIM The present study aimed to understand the relationship between pharmacological activation of mGlu4 receptors and regulation of its gene in the hippocampus. MAIN METHODS The expression level of the GRM4 gene, encoding mGluR4 receptors, was studied in the hippocampus and frontal cortex of rats after pharmacological activation of the receptor with(More)
The prolonged effect of excitotoxin (kainic acid, KA) on the morphological state of different dorsal hippocampus fields during its one-time introduction in different regions of the brain (intrahippocampal (0.2 μg/μL) and intraventricular (0.6 μg/μL)) was compared. The studies were carried out on light (cresyl violet dye) and fluorescent (fluorojade B)(More)
The expression of metabotropic glutamate receptors (mGluR2, mGluR3, mGluR4, and mGluR5) and dendritic cytoplasmic BC1 RNA in the hippocampus and frontal neocortex of Wistar rats was studied 1 and 4 weeks after intrahippocampal microinjection of kainic acid. The efficiency of glutamatergic transmission was shown to change not only in the injured hippocampus,(More)