V. G. Stygles

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The ability of indoprofen or sodium indoprofen to inhibit phenylquinone-writhing and renal prostaglandin synthesis was determined in mice following a single oral dose of either drug. Male mice (4/group) were treated with 1.5 mg/kg indoprofen or sodium indoprofen. Inhibition of phenylquinone-writhing was determined at 2, 4, 8, 16 and 32 hr post treatment.(More)
A method is described for identifying Ca++ ionophores using the protozoa Actinosphaerium. This organism is a free-floating spherical form with filamentous axopods radiating from the surface. The axopods are composed of microtubules that disaggregate upon exposure to intracellular Ca++. In the presence of an appropriate ionophore, extracellular Ca++ will(More)
Many non-steroidal anti-inflammatory, analgesic drugs appear to produce their effects by inhibiting prostaglandin synthesis. These investigations were undertaken to determine whether a new anti-inflammatory compound, indoprofen, inhibited prostaglandin synthesis in vitro when present in incubation medium or following systemic administration. The results(More)
The realtionship between in vitro prostaglandin production by renal medullary tissue and hypertension was investigated in three models of hypertensive rat, i.e., DOCA, Goldblatt and SHR. Medullary minces were incubated for 30 minutes. Following incubation tissue PGE2 concentration was quantified using mass fragmentography. Media PGE2 concentrations were(More)
The effect of tolmetin on prostaglandin synthesis by minces of rat renal medulla and on prostaglandin cyclooxygenase of rabbit renal medulla was determined in vitro. The effect of tolmetin was compared to the effects of indomethacin and ibuprofen. Pretreatment of rats in vivo with tolmetin, indmethacin or ibuprofen reduced prostaglandin synthesis by minces(More)
Increased activity of prostaglandin synthetase in spontaneously hypertensive rats (SHR) during development has previously been reported. The investigations reported herein utilized an immunofluorescent technique to qualitatively assess the activity of the first enzyme in the PGE2 biosynthetic pathway, the prostaglandin-forming cyclooxygenase (PG-C), in SHR(More)
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