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OBJECTIVE To evaluate the efficacy and adverse effects of the type B monoamine oxidase inhibitor selegiline (also known as I-deprenyl) in the treatment of Alzheimer's disease. DESIGN Long-term, double-blind, placebo-controlled trial. SETTING Seven cities (1 or 2 nursing homes in each city) in the Czech and Slovak Republics. PATIENTS A total of 173(More)
A single dose of clomipramine, 10 mg i.v., or desipramine, 25 mg i.m., was administered to seven healthy young sibling pairs in a randomized cross-over experiment. The response of serum growth hormone, prolactin and cortisol was measured. The main findings were (1) sex differences in the growth hormone and cortisol response to desipramine and (2) a(More)
Terguride is an ergoline derivative with mixed agonistic/antagonistic dopaminergic activity. This led to a paradoxical suggestion that it is effective in the treatment of both schizophrenia and parkinsonism. A total of 65 in- or outpatients with parkinsonism mostly of vascular or idiopathic etiology were included in a 4-week, open, multicenter trial.(More)
In view of the finding that dopamine is the principle neurotransmitter in the retina, an attempt was made to demonstrate dopaminergic receptor blockade by means of electroretinography. In an open experimental setting, the effect of 50 mg thioridazine was compared with that of placebo in 2 groups of 10 normal volunteers. In the placebo group, the post-drug(More)
The relationship of L-DOPA plasma level, parameters of ERG and severity of extrapyramidal symptoms after a single dose of L-DOPA was investigated in 11 patients suffering from parkinsonism of idiopathic or arteriosclerotic origin. After a drug-free night, each patient received his/her usual morning dose of L-DOPA. In the subsequent 3 h, the ERG recordings,(More)