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Brain histamine (HA) was depleted in conscious Sprague-Dawley rats by central administration of alpha-fluoromethyl-histidine (alpha-FMH), an irreversible inhibitor of the HA synthesizing enzyme. Isotonic or hypertonic saline was infused intravenously at 10 microliters.100 g-1.min-1 for 30 min and mean arterial pressure (MAP) and heart rate (HR) were(More)
The role of brain histamine (HA) in the pressor response to peripheral hyperosmolality was investigated in the conscious Sprague-Dawley rat. Increased mean arterial pressure was observed during a 30-min intravenous infusion of hypertonic saline (HTS; 10 microliters.100 g body wt-1 x min-1) in vehicle-treated controls (20.1 +/- 3.8 mmHg) and in animals(More)
Neuronal histamine (HA) in the central nervous system (CNS) has been implicated in control of peripheral cardiovascular and neuroendocrine responses. The tuberomammillary nucleus (TMN) of the posterior hypothalamus contains all CNS HA cell bodies. In these experiments, the TMN was electrically stimulated in conscious rats and HA release in the region of the(More)
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