V. Crunelli

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OBJECTIVE Absence epilepsy is a common seizure disorder in children which can produce chronic psychosocial sequelae. Human patients and rat absence models show bilateral spike-wave discharges (SWD) in cortical regions. We employed diffusion tensor imaging (DTI) in rat absence models to detect abnormalities in white matter pathways connecting regions of(More)
DNA arrays are potentially powerful experimental tools within neuroscience but application of this technology to in vivo paradigms may, in practice, be limited by the sensitivity of transcript detection and inter-screen variation. Here we describe the use of brain punch micro-sampling, used in combination with commercially available cDNA arrays, for(More)
GABA is the principal inhibitory neurotransmitter in the mammalian CNS. It acts via two classes of receptors, the GABA A , a ligand gated ion channel (ionotropic receptor) and the metabotropic G-protein coupled GABA B receptor. While synaptic GABA A receptors underlie classical 'phasic' GABA A receptor-mediated inhibition, extrasynaptic GABA A receptors(More)
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