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BACKGROUND Exposure of pregnant mothers to elevated concentrations of circulating testosterone levels is associated with fetal growth restriction and delivery of small-for-gestational-age babies. We examined whether maternal testosterone crosses the placenta to directly suppress fetal growth or if it modifies placental function to reduce the capacity for(More)
Type II diabetes originates from various genetic and environmental factors. Recent studies showed that an adverse uterine environment such as that caused by a gestational low-protein (LP) diet can cause insulin resistance in adult offspring. The mechanism of insulin resistance induced by gestational protein restriction is not clearly understood. Our aim was(More)
Pre-eclampsia is a life-threatening pregnancy disorder whose pathogenesis remains unclear. Plasma testosterone levels are elevated in pregnant women with pre-eclampsia and polycystic ovary syndrome, who often develop gestational hypertension. We tested the hypothesis that increased gestational testosterone levels induce hypertension via heightened(More)
We analyze the occurrence of vibrational resonance in a damped quintic oscillator with three cases of single well of the potential V(x)=1/2omega(0)(2)x(2)+1/4betax(4)+1/6gammax(6) driven by both low-frequency force f cos omegat and high-frequency force g cos Omegat with Omega >> omega. We restrict our analysis to the parametric choices (i) omega(0)(2),(More)
Sex steroid hormones estradiol and progesterone play an important role in vascular adaptations during pregnancy. However, little is known about the role of androgens. Plasma testosterone (T) levels are elevated in preeclampsia, mothers with polycystic ovary, and pregnant African American women, who have endothelial dysfunction and develop gestational(More)
OBJECTIVE To determine the effects of fetal sex on aromatase and androgen receptor (AR) expression in the placenta of normal and preeclamptic pregnancies. STUDY DESIGN Placentae from preeclamptic (five female and six male fetuses) and healthy pregnancies (seven female and seven male fetuses) were examined by immunofluorescence, western blotting and(More)
OBJECTIVE Examine temporal alterations in vascular angiotensin II receptors (AT(1)R and AT(2)R) and determine vascular response to angiotensin II in growth-restricted offspring. STUDY DESIGN Offspring of pregnant rats fed low-protein (6%) and control (20%) diet were compared. RESULTS Prenatal protein restriction reprogrammed AT(1a)R messenger RNA(More)
We analyze how the asymmetry of the potential well of the Duffing oscillator affects the vibra-tional resonance. We obtain, numerically and theoretically, the values of the low-frequency and amplitude of the high-frequency forces at which vibrational resonance occurs. Furthermore, we observe that an additional resonance is induced by the asymmetry of the(More)
We consider a damped quintic oscillator with double-well and triple-well potentials driven by both low-frequency force f cos (omega)t and high-frequency force g cos (Omega)t with Omega>>omega and analyze the occurrence of vibrational resonance. The response consists of a slow motion with frequency omega and a fast motion with frequency Omega. We obtain an(More)
Prenatal testosterone exposure impacts postnatal reproductive and endocrine function, leading to alterations in sex steroid levels. Because gonadal steroids are key regulators of cardiovascular function, it is possible that alteration in sex steroid hormones may contribute to development of hypertension in prenatally testosterone-exposed adults. The(More)