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Dual actions of substance P on nociception: possible role of endogenous opioids
Substance P produces analgesia when administered to mice in very small doses by the intraventricular route (1.25 to 5 nanograms per mouse). The analgesic effect can be blocked by naloxone. At higherExpand
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Hyperalgesia induced by naloxone follows diurnal rhythm in responsivity to painful stimuli.
A diurnal rhythm was observed in the responsiveness of mice to nociceptive stimuli and in the hyperalgesic activity of endogenous opioid peptides and may partly account for previous controversy overExpand
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Effects of epinephrine on resting potential in normal and hypertrophied cardiac muscles.
The role of the Na-K pump in the control of cellular ion balance has long been appreciated. Recent studies suggest that the manner in which this ion transport system functions in hypertrophiedExpand
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Dual actions of substance P on nociception: possible role of endogenous opioids : R.C.A. Frederickson, V. Burgis, C.E. Harrell and J.D. Edwards, Science, 199 (1978) 1359–1362
Substance P produces analgesia when administered to mice in very small doses by the intraventricular route (1.25 to 5 nanograms per mouse). The analgesic effect can be blocked by naloxone. At higherExpand
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