V. Aparna

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Docking and pharmacophore screening tools were used to examine the binding of ligands in the active site of thymidine monophosphate kinase of Mycobacterium tuberculosis. Docking analysis of deoxythymidine monophosphate (dTMP) analogues suggests the role of hydrogen bonding and other weak interactions in enzyme selectivity. Water-mediated hydrogen-bond(More)
Primary oral mucosal melanoma is a rare aggressive neoplasm and accounts for only 0.2-8% of all reported melanomas. It is a malignant neoplasm of melanocytes that may arise from a benign melanocytic lesion or de novo from melanocytes within normal skin or mucosa. It is considered to be the most deadly and biologically unpredictable of all human neoplasms,(More)
The World Cancer Report 2014 shows that cancer is a leading cause of death globally, and cancer related death is likely to go up by about 70 % in the next two decades. Among several target receptors of cancer, histone deacetylases are the promising therapeutic target for many cancers. The current study deals with a primary goal of identification of novel(More)
BACKGROUND Age estimation is an important factor in establishing the identity of a person. Among various techniques, dental age estimation is helpful in estimating the age in children above 16 years of age. Determination of age using developmental stages of teeth is more useful than using tooth eruption. MATERIALS AND METHODS A total of 550(More)
Myofibroblasts (MFs) are modified fibroblasts that express features of smooth muscle differentiation and were first observed in granulation tissue during wound healing. These cells play a key role in physiologic and pathologic processes like wound healing and tumorigenesis. The presence of MFs has been reported in normal oral tissues and pathologic(More)
Fatty acids have gained therapeutic attention because of their nutritional and health implications. The potentialities of different fatty acids as PLA2 binders have been analysed using molecular docking studies. Among the 46 fatty acids selected for docking studies, erucic acid and linoleic acid gave the highest glide scores. The earlier reported palmitic(More)
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