V. A. Yakhnitsa

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Changes in the background impulse activity of midbrain central gray substance neurons have been studied on slice preparations from the rat midbrain upon application of calcium-free solution, an activator of calcium channels, BAY-K 8644 (10 nM), organic (verapamil, 40 microM; D600, 10 microM; nifedipine, 1-10 microM; amiloride, 1 microM) and inorganic (Co2+,(More)
The effect of stimulation of the mesencephalic central gray matter and raphe nuclei on jaw opening reflexes evoked by excitation of high-threshold (dental pulp) and low-threshold (A-alpha) fibers of the infraorbital nerve afferents was studied in cats anesthetized with chloralose and pentobarbital. The jaw opening reflex evoked by stimulation of the dental(More)
Stimulating the midbrain central gray matter (CGM) with trains of 10–20 stimuli was found to inhibit response to electrical stimulation of infraorbital nerve and tooth pulp A-alpha and A-delta afferents at 100 msec intervals in 65% of the caudal trigeminal nucleus in neurons tested during experiments on cats under chloralose-Nembutal anesthesia. Response(More)
Effects of a selective agonist of delta-opioid receptors, BUBU, and mixed inhibitors of enkephalin-degrading enzymes, RB-38A and RB-101, on the background and evoked activity of periaqueductal gray (PAG) neurons were studied on slices of the rat midbrain. The tested drugs could either activate or depress spontaneously active neurons, or exert no influence(More)
A study was done on base activity and changes in base activity (BA) of neurons in periaqueductal gray matter (PAG) during stimulation of monoaminergic structures of the brainstem: the nucleus raphe magnus (NRM), the locus coeruleus (LC), and the substantia nigra (SN), in rats anesthetized with hexenal (200 mg/kg). Three types of PAG neurons that differed in(More)
The effects of severing the spinal trigeminal tract and its caudal nucleus on high-threshold jaw-opening reflex elicited by tooth pulp stimulation were investigated during experiments on cats under chloralose-Nembutal anesthesia. Low-threshold jaw-opening reflex produced by stimulating the A-α-infraorbital nerve at an intensity 2–3 thresholds in relation to(More)
The effects were studied in waking cats of brief stimulation (20 stimuli at a rate of 400 Hz) of the central gray matter (CGM) and dorsal raphe nucleus (DRN) on high-threshold jaw-opening reflex (HJOR) evoked by tooth pulp stimulation during blockade of serotonin synthesis produced by application of 300 mg/kg parachlorophenylalanine (PCPA) i.p. Inhibitory(More)
Effects of aspartate (2 · 10−5 M), substance P (10−7–10−8 M), and serotonin (5-hydroxytryptamine, 5-HT; 5 · 10−5 M) on the background activity of neurons in the central gray substance (CGS) were studied on slices of the rat midbrain. Aspartate and substance P (transmitters of nociceptive signals), and 5-HT (modulator of transmission of nociceptive(More)
The changes in the background activity (BA) of neurons of the central gray substance upon the iontophoretic application of serotonin (ST) to them in a concentration of 1·10−4 mole/liter, and following the blockage of its synthesis by pchlorophenylalanine (PCPA), were investigated in hexenal-anesthetized rats. The application of ST led to changes in the BA(More)
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