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Surfactant-BL was administered to rats via the inhalation route from day 1 or day 8 after intratracheal injection of bleomycin. Bronchoalveolar lavage and morphological characteristics of the lungs were compared. Administration of surfactant-BL at the early terms efficiently reduced the severity of bleomycin-induced alveolitis and atelectases.
Rats were exposed to inhalation of surfactant-BL starting from the first or eighth day after intratracheal administration of bleomycin. At the early stages, the preparation effectively attenuated damage to ultrastructural components of the lung tissue and reduced the severity and extent of subsequent pulmonary pathology.
In experiments on mice it was established that the radiosensitizing effect of xanthobin was manifested by the enhancement of the inhibiting action of ionizing radiation on the growth of adenocarcinoma RL-67, diminution of the "shoulder" of the survival curve of Ehrlich ascites tumor cells, and increase in the average life of tumor-bearing animals.
The macrophageal elements (ME) of bronchoalveolar lavage were cytologically and electron microscopically studied in 11 patients with active pulmonary tuberculosis who took antituberculous drugs during 3-6 months, which did not yield a significant clinical effect (Group 1) and in 24 patients with the disease who received inhaled C-BL during chemotherapy… (More)
Morphological and histoenzymatic changes in cells of the spinal cord and spinal ganglia after epidural injection of a combination of prosidol with clonidine were studied on dogs. No pathological structural and metabolic changes in the nervous tissue were found after combined treatment with the test drugs. Higher activity of nucleic acids and alkaline… (More)
In experiments on mice it was established that 8-azahypoxanthine has a slight radiosensitizing effect on haemopoietic stem cells and leucotic cells. The pattern of the changes observed has prompted an assumption that the preparation used has an inhibitory action on the post-irradiation recovery.
Morphological and quantitative histoenzymological changes in neurons of dog spinal cord and spinal ganglion were studied in acute and chronic experiments with epidural administration of 0.01% clofelin. No morphofunctional changes were revealed after bolus injection of clofelin in a single dose of 6.5 mg/kg. After administration of clofelin in a daily dose… (More)
The work is based on a clinical-laboratory analysis of the pulsatile and non-pulsatile regimens of artificial blood circulation. During operation under investigation were indices of gases of the arterial and venous blood. They were compared with those of gases obtained using the monitor of transcutaneous gases of blood. In the postoperative period a… (More)