V. A. Magaldadze

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Strophanthin K and beta-acetyldigoxin in vitro in concentration of 10(-6) M in TAM sharply increased the force generated by isolated myocardial contractile protein system (MCPS), and normalized the work performed by the system. This was accompanied by increase of ATP internal energy release (enthalpy) intensity, while a portion of energy, dissipating into(More)
One of the main causes of heart failure in inflammatory diseases of the myocardium is a sharp decrease in the ability of the myocardial contractile protein system (MCPS) to generate force and perform work [5]. It has also been shown on a model of toxico-allergic myocarditis (TAM) that in inflammatory lesions of the heart muscle what happens is not simply a(More)
Heat accompanying the interaction between relaxed and contracted glycerinized fiber bundles of the striated muscles of rats and ATP was measured. Investigation of the interaction concerned both relaxed and preliminarily contracted bundles. As apparent from the thermokinetic curves, the interaction of ATP with the noncontracted bundles yields a peak of the(More)
The heat production accompanying interaction between bundles of glycerinized fibers of rat striated muscles and ATP was measured. Interaction both of relaxed and of initially contracted bundles was investigated. The kinetic temperature curves show that during interaction between ATP and the uncontracted bundle a peak of thermal power is observed to coincide(More)
It was shown in experiments on myocardial fiber bundles (MGFB) from normal heart that strophantin K and beta-acetildigoxin in vitro in concentration of 10(-6) M sharply increased the value of force generated by contractile protein system and its ability to perform work. In this case strophantin K significantly increased energy transformation efficiency. It(More)
Experiments on bundles of myocardial fibers with a loosened sarcolemma (which had lost its selective permeability and allowed such large molecules as ATP and CG to pas through freely), with differentially destroyed or functionally inactivated organelles, undertaken previously showed that CG act on intracellular structures of the cardiomyocyte~ that $~acetvl(More)
The in vitro study on an isolated system of myocardial contractile proteins determined optimal concentrations of the positive inotropic action and biological activity ranges of beta-methyldigoxin (beta-MD), strophanthin K, K-strophantozide, beta-acetyldigoxin (beta-AD), milrinone, and amrinone. Optimal concentrations of the beta-MD and strophanthin K(More)