V. A. Likhoshvai

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BACKGROUND AND AIMS The root apical meristem (RAM) is the plant stem cell niche which provides for the formation and continuous development of the root. Auxin is the main regulator of RAM functioning, and auxin maxima coincide with the sites of RAM initiation and maintenance. Auxin gradients are formed due to local auxin biosynthesis and polar auxin(More)
Theoretical investigation of properties of assumed gene networks constructed from elementary units of two types, genetic elements and control links, was carried out. A test was formulated for a subclass of such networks with cyclic structure called S(n,k) networks allowing calculation-free prediction of the network limit properties (the presence/absence and(More)
As an RNA virus, hepatitis C virus (HCV) is able to rapidly acquire drug resistance, and for this reason the design of effective anti-HCV drugs is a real challenge. The HCV subgenomic replicon-containing cells are widely used for experimental studies of the HCV genome replication mechanisms, for drug testing in vitro and in studies of HCV drug resistance.(More)
Gene expression is known to correlate with the degree of codon bias in many unicellular organisms. However, such a correlation is not observed in some organisms. It was demonstrated that inverted complementary repeats within coding DNA sequences (ORFs) should be considered for proper estimation of the translation efficiency because they can form secondary(More)
The life cycle of human immunodeficiency virus type-1 (HIV-1) makes possible the realization of regulatory strategies that can lead to complex dynamical behavior of the system. We analyze the strategy which is based on two feedback mechanisms, one mediating a positive regulation of the virus replication by Tat protein via the antitermination of the genomic(More)
The review describes several modules of the GeneExpress integrated computer system concerning the regulation of gene expression in eukaryotes. Approaches to the presentation of experimental data in databases are considered. The employment of GeneExpress in computer analysis and modeling of the organization and function of genetic systems is illustrated with(More)
Determination of the efficiency of the organism gene expression is a topical and important problem of modern biology. Microorganisms that parasitize on human and domestic animals are of special interest. In the study, bioinformatic analysis of genomes of 62 bacteria strains belonging to the Mycoplasma genus was carried out. It was demonstrated that the(More)
Due to a high toxicity of nitrite and its metabolites, it is of high interest to study mechanisms underlying the low NO2 level maintenance in the cell. During anaerobic growth of Escherichia coli the main nitrite-reducing enzymes are NrfA and NirB nitrite reductases. NrfA reductase is localized in the cell periplasm and uses NO2 as an electron acceptor to(More)
Any vital activities of the cell are based on the ribosomes, which not only provide the basic machinery for the synthesis of all proteins necessary for cell functioning during growth and division, but for biogenesis itself. From this point of view, ribosomes are self-replicating and autocatalytic structures. In current work we present an elementary model in(More)
The problem of coordinating genome replication with cell growth in bacteria was posed over four decades ago. Unlike for eukaryotes, this problem has not been completely solved even for Escherichia coli, which has been comprehensively studied by molecular biologists, to say nothing of other bacteria. Current models of the bacterial life cycle solve the(More)