V. A. Davydova

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Derivatives of glycyrrhyzic acid (GA), a triterpene glycoside, exhibit a wide spectrum of pharmacological activity in advantageous combination with low toxicity [1 -5 ] . This article reports on the synthesis of new GA amides (II), synthesized by acylation of biogenic amines with glycyrrhyzic acid in the presence of N,N'-dicyclohexylcarbodiimide (DCHC). The(More)
Hemisuccinates, hemiphthalates, acetylsalicylates, cinnamates, andp-methoxycinnamates of lupeol, betulin, and 3-O-acetylbetulin were synthesized via interaction with corresponding acid anhydrides or acid chlorides. A number of betulin esters in position 3 and 28 were shown to exhibit a pronounced hepatoprotective effect similar to that of betulin and(More)
In the previous works of this series [1 -3 ] we have demonstrated that derivatives of 2,2-dicyclohexylsulfide, 2,5-dim ethylene1-thiacyclopentane, and 13-thiabicyclo [8.2.1 ]-5tridecene exhibit antiinflammatory activity in combination with low toxicity. The purpose of this work was to synthesize new compounds belonging to the group of(More)
The 18]3-GA isomer, extracted from the root of licorice (Glycyrrhiza glabra L. and Glycyrrhiza uralensis F.) [3], as well as its 18ct-GA counterpart exhibit a broad spectrum of pharmacological activity, producing antiinflammatory, antiallergic, antiviral, expectorant, antitumor, and antiulcer effects [ 4 10]. The two GA isomers possess close physicochemical(More)
The main disadvantage inherent in common antiinflammatory drugs of both steroidal and nonsteroidal types (ortopher~ indomethacin, acetylsalicylic acid, prednisolone, etc.) is the irritating action upon the gastrointestinal tract [1 -3]. The search for new antiinflammatory drugs free of this side effect is a currently important task. Glycyrrhizic acid (I)(More)
The well known nonsteroidai antiinflammatory drugs (NAID) which are used extensively in medical practice, such as acetyisalicylic acid (ASA), butadione, orthofen (voltaren), brufen, and indomethacin, have a number of side effects, in particular uicerogenic effects in the gastrointestinal tract, ieukopenia, and allergic effects [i]. The use of these drugs in(More)
The works of Bentley [4-7] marked the beginning of the search for medically promising thebaine derivatives [4-7]. The availability of this alkaloid, the impossibility of its direct use as a drug, as well as the unquestionable success of investigative searches in the last two decades, have stimulated the continual interest of chemists and pharmacologists in(More)
Glycyrrhizic acid and its aglycon-glycyrrhetic ac id are found as components in the root extracts from licorice plants of the Glycyrrhizia glabria and Glycyrrhizia uralensis species. Glycyrrhizic acid and its derivatives are known to possess a broad spectrum of pharmacological activity (antiinflammatory, antiulcer, immunomodulating, and antiviral) and are(More)
We have d e s c r i b e d the s y n t h e s i s of t h e k e t o n e I I I used as t h e s t a r t i n g r e a g e n t in a p r e v i o u s work [ 3 ] . The r e a c t i o n s were c a r r i e d ou t a t room t e m p e r a t u r e by mix ing compound I s w i t h t h e a p p r o p r i a t e amine in m e t h a n o l . Rep lacement o f t he c h l o r i n e atom(More)