V. A. Brattsev

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125I-p-iodophenyllaurate proved to be a suitable substrate of lipase for studies of pancreas lipolytic function in vivo and in vitro. After peroral administration into rats the drug was hydrolyzed by lipase. The liberated 125I-p-iodophenol was absorbed in intestine and excreted with urine either as free 125I-p-iodophenol or its conjugates. Activity of(More)
An urgent problem in modem radiooncology, aimed at increasing the efficacy of beam and combined treatment of malignant tumors, consists in selecting methods to provide maximum targetted tumor cell damage with minimum harm to the normal tissues surrounding the malignancy. Development of new beam therapy techniques has led researchers to a binary action(More)
Previously it was established that the new compound rhodandodecaborate [Bt2HIISCN] 2 (BSCN) is a promising preparation for boron neutron capture therapy (NCT). Administration o f BSCN led to the accumulation o f boron in experimental tumors (B-16 melanoma and glyoblastoma) in greater amounts as compared to those observed for the well-known analog [BI2HIISH](More)
C57BL/6 male mice bearing subcutaneously transplanted melanoma B-16 were used to study the applicability of 5-iodine-2'-deoxyuridine labeled with iodine 125 and 131 radionuclides to assess individual tumor response to radiation. The experiments using intact animals and those locally irradiated in the dose of 10 Gy revealed a correlation between excretion of(More)
Since the beginning of implementation of the method of boron neutron capture therapy (BNCT), several hundred boron-containing compounds have been synthesized for this purpose. The main requirement of these substances is the ability to be taken up by tumor cells with insignificant accumulation in the surrounding tissues. After many years of investigations(More)
Experience gained in the clinical use of boron neutron capture therapy (NCT) for the treatment of malignant neoplasms stimulates the further development of this method [1]. Stage I and II clinical tests on the application of NCT with domestic sodium mercaptododecaborate Na2B12H11SH (BSH) [2] to the treatment of melanoma in a restricted number of patients(More)
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