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Functional characterization of human IgG, IgM, and IgA antibody directed to the capsule of Haemophilus influenzae type b.
Antibody to the capsular polysaccharide (CP) of Haemophilus influenzae b (Hib) is bactericidal, opsonic, and protective. Minimum protective levels of primarily IgG antibody to Hib CP, calculated from… Expand
Correlation of the Km(1) immunoglobulin allotype with anti-polysaccharide antibodies in Caucasian adults.
- D. Ambrosino, V. Barrus, G. G. deLange, G. Siber
- Medicine, Biology
- The Journal of clinical investigation
- 1 August 1986
Km allotype antigens are serologic markers expressed on kappa light chains of human immunoglobulins. To determine whether th Km phenotype of an individual is related to his ability to make antibodies… Expand
Decreased protective efficacy of reduced and alkylated human immune serum globulin in experimental infection with Haemophilus influenzae type b.
Conventionally prepared immune serum globulin frequently produces severe side effects when administered intravenously. A modified preparation in which 4 to 5 interchain disulfide bonds have been… Expand
COMPARISON OF NATIVE AND REDUCED AND ALKYLATED HUMAN IV IMMUNE SERUM GLOBULIN (ISG) IN EXPERIMENTAL H. IN FLUENZAE TYPE B INFECTION
Reduced and alkylated (RA) ISG for intravenous use contains IgG with disrupted inter-heavy chain disulfide bonds. This change alters Fc function, particularly the ability to fix complement. We… Expand