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Functional characterization of human IgG, IgM, and IgA antibody directed to the capsule of Haemophilus influenzae type b.

• John R. Schreiber, V A Barrus, Kenneth Cates, George R. Siber
• The Journal of infectious diseases
• 1986

Antibody to the capsular polysaccharide (CP) of Haemophilus influenzae b (Hib) is bactericidal, opsonic, and protective. Minimum protective levels of primarily IgG antibody to Hib CP, calculated from… (More)

Correlation of the Km(1) immunoglobulin allotype with anti-polysaccharide antibodies in Caucasian adults.

• Donna M. Ambrosino, V A Barrus, G G Delange, George R. Siber
• The Journal of clinical investigation
• 1986

Km allotype antigens are serologic markers expressed on kappa light chains of human immunoglobulins. To determine whether th Km phenotype of an individual is related to his ability to make antibodies… (More)

Decreased protective efficacy of reduced and alkylated human immune serum globulin in experimental infection with Haemophilus influenzae type b.

• John R. Schreiber, V A Barrus, George R. Siber
• Infection and immunity
• 1985

Conventionally prepared immune serum globulin frequently produces severe side effects when administered intravenously. A modified preparation in which 4 to 5 interchain disulfide bonds have been… (More)

COMPARISON OF NATIVE AND REDUCED AND ALKYLATED HUMAN IV IMMUNE SERUM GLOBULIN (ISG) IN EXPERIMENTAL H. IN FLUENZAE TYPE B INFECTION

• John R. Schreiber, V A Barrus, George R. Siber
• Pediatric Research
• 1984

Reduced and alkylated (RA) ISG for intravenous use contains IgG with disrupted inter-heavy chain disulfide bonds. This change alters Fc function, particularly the ability to fix complement. We… (More)

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