V. A. Arefolov

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The antistress affect of the substance P1-4 N-terminal fragment (ARG-Pro-Lys-Pro, 100 mkg/kg, i.p.) has been studied on the model of immobilization stress in rats. It was ascertained that the preparation of protective effect is revealed to the greatest extent on the exhaustion stage (48 h of immobilization), which served to prevent the lymphoid organs mass(More)
Independent peptide fragments of pro-opiomelanocortin molecule, beta-endorphin and ACTH, have been detected immunohistochemically in the adrenal glands of rats and mice. Immunoreactive beta-endorphin and ACTH have been revealed in the adrenal medulla and reticular zone of the adrenal cortex. beta-endorphin and ACTH distribution patterns in adrenal sections(More)
Methods of physiological analysis were used to study the effect of the original psychotropic agent carbidine on adenergic neurotransmission on the isolated rat vas deferens as the model. The content of noradrenalin (NA) was determined spectrofluoremetrically in the same ducts and the ability of the neuroleptic to block the uptake of exogenous NA by the(More)
Experiments were carried out on male rats weighing 180 • 30 g. The animals were immobolized by fixing them securely in special frames for 30 min and I, 4, and 24 h. After decapitation of the rat the thymus, spleen, and adrenals were weighed, and the state of the gastric mucosa was studied. Lipids were detected histochemically in the adrenal cortex [5] and(More)
Fluorescent microscopy and spectrofluorometry of biogenic amines were used to study adrenergic innervation of the dura mater, vas deferens and medullary substance of the adrenals in immobilized rats treated with phenazepam. It was established that phenazepam (1 mg/kg, i. p.) prevented the decrease in the level of the adrenergic transmitter at the stage of(More)
The effect of new tetracyclic antidepressants pyrazidol and inkazan on adrenergic neurotransmission in the isolated rat vas deferens was studied by examining vas deferens contractions in response to the transmural electric stimulation of the postganglionic sympathetic nerves and addition of noradrenaline (NA) or BaCl2. Pyrazidol and inkazan were found to be(More)
The effect of a new antianginal preparation, nonachlazine, on adrenergic neurotransmission in the isolated rat vas deferens was studied by recording contractions of the duct in response to transmural stimulation of postganglionic sympathetic nerves by the electric current or by application of noradrenalin (NA) or BaCl2. The effect of nonachlazine on the NA(More)
It has been shown that carbidine increases the level of homovanillic acid (HVA) in the corpus striatum of the rat brain. The changes in HVA level allowed forming a judgement on dopamine turnover. By the intensity of this effect, carbidine proved inferior to typical neuroleptics--triphtazine and ftorfenazin. The antidepressant ftoracizin did not alter HVA(More)
Ultrastructural organization of chromaffin cells of rat adrenal glands was studied in different stress models (48 h of running in the wheel, 48 h of immobilization, and sleep deprivation during 7 days). It was shown by ultrastructural morphometry that chromaffin cells experienced fine structural modifications (a decrease in the number of adrenaline- and(More)
By employing fluorescent histochemistry and spectrofluorimetry the influence of an original psychotropic substance -- carbidine on the level, localization and accumulation of the adrenergic mediator in Vas deferens, dura mater and the kidney capsule was studied "in vivo" and "in vitro". Carbidine was shown to capable of liberating the adrenergic mediator(More)