V. A. Aleksandrov

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After administration of a single dose (by mouth) of a series of symmetrical dialkylnitrosamines (nitrosodimethylamine — NDMA, nitrosodiethylamine — NDEA, and nitrosodibutylamine — NDBA) to rats in the maximal doses tolerated by pregnant animals (NDMA, 30 mg/kg; NDEA 200 mg/kg; NDBA 1200 mg/kg), only an increase in the mortality among the embryos was(More)
The clinical trial of a new drug "mamoclam" was carried out in patients with benign breast disease. The drug contains omega-3 polyunsaturated fatty acids, iodine and chlorophyll derivatives and is produced from the brown sea alga laminaria. The study involved 33 patients (mean age 42.5 +/- 1.1 yrs). Two tablets were administered thrice a day for three(More)
The paper reports the results of the experimental and clinical evaluation of the administration of drugs prepared from flowers of Filipendula ulmaria (L.) Maxim for cervical dysplasia and cancer treatment. Local administration of decoction resulted in a 39% drop in the frequency of squamous-cell carcinoma of the cervix and vagina induced in mice by(More)
The influence of official drug bioginseng produced from cultivated cells of ginseng radix (Panax ginseng C. A. Mey) on carcinogenesis of the mammary gland was studied. Adenocarcinomas of the mammary gland were induced in rats by single intramammary injections of N-methyl-N-nitrosourea (MNU) at a dose of 1 mg per gland into the tissues of all 12 mammary(More)
The F1 female rats exposed to N-nitrosomethylurea (NMU) in dose 20 mg/kg on the 21st day of gestation and postnatal induction of persistent estrus syndrome revealed an increased incidence of tumours of the central nervous system (CNS) as compared to F1 exposed to NMU transplacental action only (25.0-2.5%, respectively). Carcinogenic effect was observed in(More)
Three models of cancerogenesis were used to test the anti-cancerogenic effects of pentoxiphylline. In female rats, breast adenocarcinoma was induced by intramammary injections of N-methyl-N-nitrosourea (MNU) or colonic and rectal adenocarcinomas by intrarectal instillations of MNU. In female mice, squamous cell carcinomas of the cervix uteri and vagina were(More)
Embryos died and a teratogenic effect followed combined intragastric administration of methylurea (MU) and sodium nitrite (SN) to rats on the 9th day of pregnancy; this was caused by the endogenous synthesis of nitroso-methylurea which produced a pathogenic action. Ascorbic acid and urotropine completely blocked the possibility of manifestation of the(More)
The effects of nonsteroidal and steroidal drugs ortophen and dexamethasone on carcinogenesis of the uterine cervix and vagina were studied on mice. Intravaginal applications of a 0.1% solution of 7,12-dimethylbenz(a)anthracene, 2 times a week for 8 weeks, induced cervical and vaginal carcinomas in 67% of cases in 35 weeks. Ortophen (20 mg/l of drinking(More)
As shown by the morphometric method of Sjöström et al., changes in the weight of pararenal adipose tissue during pregnancy in rats were connected with the changes in the size and not in the count of adipocytes. The character of adipose tissue changes occurring after birth depended mainly on the mode of the ratlings feeding. In case of normal feeding the(More)