Recent studies link synaptojanin 1 (synj1), the main phosphoinositol (4,5)-biphosphate phosphatase (PI(4,5)P2-degrading enzyme) in the brain and synapses, to Alzheimer disease. Here we report a novel mechanism by which synj1 reversely regulates cellular clearance of amyloid-β (Aβ). Genetic down-regulation of synj1 reduces both extracellular and… (More)
An increase in amyloid-β (Aβ) production is a major pathogenic mechanism associated with Alzheimer's disease (AD), but little is known about possible homeostatic control of the amyloidogenic pathway. Here we report that the amyloid precursor protein (APP) intracellular domain (AICD) downregulates Wiskott-Aldrich syndrome protein (WASP)-family verprolin… (More)
Neurotoxic amyloid-β peptides (Aβ) are major drivers of Alzheimer's disease (AD) and are formed by sequential cleavage of the amyloid precursor protein (APP) by β-secretase (BACE) and γ-secretase. Our previous study showed that the anticancer drug Gleevec lowers Aβ levels through indirect inhibition of γ-secretase activity. Here we report that Gleevec also… (More)
This report is released to inform interested parties of ongoing research and to encourage discussion of work in progress. Any views expressed are those of the author and not necessarily those of the U.S. Census Bureau. Please direct questions to the Net International Migration Branch by phone 301-763-9379 or email email@example.com.… (More)
Curves are given for the magnetic field along the axis between two circular coils of square section traversed by the same current. These curves relate the field variations, the length in which the field is within a certain allowed variation, the coil thicknesses, and their separation.