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BACKGROUND Bone marrow (BM) cells are promising tools for vascular therapies. Here, we focused on the possibility of targeting the hypoxia-induced pulmonary artery hypertension remodeling with systemic delivery of BM-derived mesenchymal stem cells (MSCs) into non-irradiated rats. METHODS Six-week-old Wistar rats were exposed to 3-week chronic hypoxia(More)
BACKGROUND There is currently little support to understand which pathological factors led to differences in tumor texture as measured from FDG PET/CT images. We studied whether tumor heterogeneity measured using texture analysis in FDG-PET/CT images is correlated with pathological prognostic factors in invasive breast cancer. METHODS Fifty-four patients(More)
We aimed to assess the accuracy of Doppler tissue imaging (DTI) in detecting right ventricle (RV) dysfunction and electromechanical coupling alteration following pulmonary hypertension (PHT) in rat. PHT was induced by chronic hypoxia exposure (hypoxic PHT) or monocrotaline treatment (monocrotaline PHT). In both PHT models, we observed transparietal RV(More)
Exercise training and hypertension induced cardiac hypertrophy but modulate differently left ventricle (LV) function. This study set out to evaluate cardiac adaptations induced by moderate exercise training in normotensive and untreated severe hypertensive rats. Four groups of animals were studied: normotensive (Ctl) and severe hypertensive (HT) Wistar rats(More)
This paper presents a method to analyze the local wall motion of the left ventricle of the heart. Data are sets of points (obtained from various medical imaging modalities) corresponding to surfaces of the left ventricle, which evolve as a function of time. After re-sampling, the surfaces are segmented in order to create regions of equivalent volume. Then,(More)
1.0 INTRODUCTION Now is an exciting time to be in the field of Upper-Limb Prosthetics. Due to the limited function of current commercially available upper-limb prosthetics and the increased incidence of amputation injuries being seen in Operation Enduring Freedom (OEF-Afghanistan) and Operation Iraqi Freedom (OIF) a number of new initiatives have been put(More)
We aimed to investigate the toxicity of carbon monoxide (CO) in rats with right ventricle (RV) remodeling induced by hypoxic pulmonary hypertension (PHT). A group of Wistar rats was exposed to 3-wk hypobaric hypoxia (H). A second group was exposed to 50 ppm CO for 1 wk (CO). A third group was exposed to chronic hypoxia including 50 ppm CO during the third(More)
OBJECTIVE We aimed to describe a pattern of rim uptake observed in lung infarction on FDG-PET/CT, called the "rim sign." It was defined as a continuous slight FDG uptake along the border of a subpleural consolidation without uptake within the consolidation. METHODS We retrospectively reviewed the FDG-PET/CT studies of 400 patients referred for thoracic(More)
OBJECTIVES In this study, the role of rho-kinase activity in the modulation of vascular contractility induced by hemin, a heme oxygenase inducer, was investigated. METHODS Aortic rings from Wistar rats were incubated in physiological saline solution (PSS) containing hemin at 10-(4) M for six hours then contracted with phenylephrine, and a dose-response(More)
The aim of the work presented here is to compare two new 3D methods of cardiac kinetic analysis with the standard 2D radio nuclide angiography (ERNA). The first new method is a geometric method, based on the evolution of the ventricular 3D reconstruction, obtained after segmentation. The second method directly relies on isotopic data, without segmentation(More)
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