Véronique Agin

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This study examines whether or not habituation contributes to the regulation of the inhibition of predatory behavior observed during the "prawn-in-the-tube" training procedure. When presented with prawns that are visible behind glass but untouchable, cuttlefish promptly learn to inhibit their capture attempts. The first three experiments demonstrated that(More)
BACKGROUND AND PURPOSE Early reperfusion using tissue-type plasminogen activator is the only therapeutic agent to treat focal cerebral ischemia with proven efficacy in patients. Nevertheless, novel insights into the pathophysiology of neurons, glial cells, and the fate of the endothelium after stroke call for the use of new strategies to improve stroke(More)
Cuttlefish quickly learn to inhibit their predatory motor pattern when shown prawns in a glass tube. The available literature suggests that cuttlefish show an excellent retention between 2 and 8 min, a recovery of the predatory responses around 20 min and good retention after 1 h of the training phase. These results have been considered as the product of(More)
The inhibition of predatory behavior observed during the "prawn-in-the-tube" procedure has been extensively used in studies of cuttlefish learning. The present study examines the effect of age on the conditioning of this response in the cuttlefish, Sepia officinalis. Data show that a significant increase in acquisition performance occurs between 15 and 21(More)
BACKGROUND The lack of a relevant stroke model in large nonhuman primates hinders the development of innovative diagnostic/therapeutic approaches concerned with this cerebrovascular disease. Our objective was to develop a novel and clinically relevant model of embolic stroke in the anesthetized monkey that incorporates readily available clinical imaging(More)
Using cytochrome oxidase (CO) histochemistry, the effects of instrumental conditioning in cuttlefish central nervous system were examined. The posterior superior frontal lobe showed an increase of CO labelling just after training, whereas the anterior superior frontal lobe exhibited a decrease of CO staining 24 h post-training. These findings provide the(More)
BACKGROUND AND PURPOSE The aim of the present study was to investigate the effects of normobaric oxygen (NBO) therapy on T2*-weighted images of intracranial hemorrhages (ICHs). METHODS Two common models of ICH were performed in mice, and longitudinal T2*-weighted images of the hematomas were acquired under normoxia or NBO. The effects of NBO were also(More)
Numerous treatments have been reported to provide a beneficial outcome in experimental animal stroke models; however, these treatments (with the exception of tissue plasminogen activator) have failed in clinical trials. To improve the translation of treatment efficacy from bench to bedside, we have performed a preclinical randomized controlled multicenter(More)
The cuttlefish is an active predator that is able to catch crabs of a size that is large relative to its own. The capture is followed by a complex manipulative behavior leading to paralysis of the prey by injection of a cephalotoxin. This manipulative behavior is relatively stereotyped, and earlier research has shown that the cuttlefish concentrates its(More)
In humans, spatial cognition and navigation impairments are a frequent situation during physiological and pathological aging, leading to a dramatic deterioration in the quality of life. Despite the discovery of neurons with location-specific activity in rodents, that is, place cells in the hippocampus and later on grid cells in the entorhinal cortex (EC),(More)