Uzodinma N. Uche

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Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), infects one third of the world's population. Among these infections, clinical isolates belonging to the W-Beijing appear to be emerging, representing about 50% of Mtb isolates in East Asia, and about 13% of all Mtb isolates worldwide. In animal models, infection with W-Beijing(More)
Assembly of TCR and TCR genes from the TCR / locus is tightly controlled for the proper generation of and T cells. Of >100 shared variable gene segments in the TCR / locus, only a few are predominantly used for the TCR gene assembly, while most are for TCR . However, the importance and mechanisms of the selective variable gene rearrangement for T cell(More)
Assembly of TCRalpha and TCRdelta genes from the TCRalpha/delta locus is tightly controlled for the proper generation of alphabeta and gammadelta T cells. Of >100 shared variable gene segments in the TCRalpha/delta locus, only a few are predominantly used for the TCRdelta gene assembly, while most are for TCRalpha. However, the importance and mechanisms of(More)
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