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BACKGROUND AND OBJECTIVES Cerebrovascular and cardiac adverse events can be significantly reduced by effective antihypertensive therapy; however, BP control rates remain poor. The objective of this randomized, double-blind, parallel-group, multicentre study was to determine the efficacy and safety of olmesartan medoxomil/amlodipine combination therapy in(More)
BACKGROUND Treatment guidelines recommend combination therapy to control blood pressure (BP) in the majority of hypertensive patients. This long-term open-label study assessed a treatment algorithm based on olmesartan medoxomil (hereafter olmesartan), amlodipine and hydrochlorothiazide (HCTZ). METHODS Patients with moderate-to-severe hypertension who were(More)
Charcot-Marie-Tooth disease is the most common inherited neuropathy and a duplication of the peripheral myelin protein 22 gene causes the most frequent subform Charcot-Marie-Tooth 1A. Patients develop a slowly progressive dysmyelinating and demyelinating peripheral neuropathy and distally pronounced muscle atrophy. The amount of axonal loss determines(More)
BACKGROUND AND OBJECTIVE Hypertension remains a major global health problem, and evidence suggests that the majority of patients will require two or more antihypertensive agents in order to reach specified BP targets. Combining two drugs from different classes has the potential to target different aspects of hypertension, which may result in additional BP(More)
BACKGROUND A post-hoc analysis was performed on the data from a 54 weeks phase III study (ClinicalTrials.gov identifier: NCT00923091) to measure changes in the health-related quality of life (HRQoL) of 2,690 patients aged ≥18 with moderate-to-severe hypertension who received one of six doses of olmesartan/amlodipine/hydrochlorothiazide (OLM/AML/HCTZ), using(More)
Of 563 patients with fractures of the ankle joint who received conservative treatment between 1962 and 1967, a follow-up examination was performed in 100. Of 280 patients undergoing surgical treatment between 1965 and 1970, 105 presented for follow-up examination. The findings were evaluated according to strict criteria laid down by Weber. Only 45% of the(More)
Die operative Behandlung der Knöchelfrakturen hat sich in den letzten Jahren zu recht durchgesetzt. Anhand eines Kollektivs von 100 konservativ behandelten Malleolarfrakturen und eines zweiten von 105 operativ behandelten läßt sich insofern eine Aussage machen, als beide Gruppen nach den gleichen Kriterien kontrolliert und bewertet wurden. Maßstab hierfür(More)
After > 10 000 treatments – our HM3/4 and MPL 9000 have been replaced by the Siemens Lithostar multiline. As a ESWL center with ESWL as the primary treatment indication for all types of stones in kidney and ureter we report our initial experience with this new multifunctional lithotripter. The system consists of an electromagnetic shock-wave emitter (Focus(More)
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