Uttam Kumar Khamrai
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Caenorhabditis elegans requires sterol, usually supplied as cholesterol, but this is enzymatically modified, and different sterols can substitute. Sterol deprivation decreased brood size and adult… (More)
A number of N-substituted cyclic enediynes (azaenediynes) have been synthesized via Pd(0)-catalysed ene–yne coupling followed by N-alkylation. The simplest of them, a 10-membered monocyclic enediyne… (More)
Abstract The reaction of [(4 S )-2-oxo-4-phenyloxazolidin-3-yl]acetic acid chloride with N -methylidene-bis-[(trimethylsilyl)methyl]amine and triethylamine in refluxing chloroform leads to a… (More)
Remarkableasymmetricinduction is achieved in the alkylation of the lithium enolate of the β-lactam 1. This allows the first time access to a new family of peptidomimetics 2 with predictable… (More)
The synthesis of a novel bispropargyl sulphone 1 has been described. The strained β-lactam ring acts as a lock thereby arresting the isomerization to allene.
Abstract Monocyclic β-lactams 1–3 substituted at C-4 with enediyne moiety have been synthesized via Pd(0) mediated coupling reaction. Their antibacterial activity against ampicillin-resistant E. coli… (More)
Abstract Palladium mediated regio and stereospecific syntheses of exomethylene benzo-and naphtho dioxans are described.