BACKGROUND A number of studies have reported evidence of cognitive deficits in euthymic bipolar patients. Qualitative reviews of the literature have indicated impairments in executive functions and declarative memory are most consistently reported. However, not all primary studies conducted to date have had sufficient power to detect statistically… (More)
BACKGROUND Neurocognitive deficits exist in euthymic patients with bipolar disorder, but relationships between symptoms, psychosocial and neurological factors remain uncertain. AIMS To measure neurocognitive function in bipolar disorder and explore links to sub-syndromal mood symptoms, soft neurological signs and psychosocial impairment. METHOD… (More)
OBJECTIVE Although it is established that euthymic bipolar patients have neurocognitive deficits, the influence of medication on their cognitive performance is uncertain and requires investigation. METHOD Neuropsychological tests of executive function, memory and attention were performed on 44 prospectively verified, euthymic bipolar I patients, 22 of… (More)
Two cases are reported in which simple writer's cramp turned into dystonic writer's cramp without progression to generalized dystonia. Such a transition casts doubt on the conventional nosological status of writer's cramp as a functional motor disorder related to occupation; it suggests that the condition may be minor manifestation of focal dystonia.
BACKGROUND ECT, though not favoured in the West for treating schizophrenia, is regularly practiced in India for this indication, particularly in poorly responding/treatment resistant cases.Therefore, its role in treatment-resistant schizophrenia is a subject of systematic investigation. AIM To compare the effectiveness and safety of Electroconvulsive… (More)
Recently, the Drugs Controller General of India (DCGI) has written to several organizations seeking information on their infrastructure for drug trials. The DCGI was actually trying to figure out the Good Clinical Practice (GCP) training requirements at the national level. The DCGI wishes to build up a pool of GCP trained clinicians in the country by… (More)
Although successfully used, caution has been advised with the combined use of clozapine and electroconvulsive therapy (ECT).The combination has been associated with delirium, in this report, which successfully resolves on discontinuation of ECT.
In this study, the prognostic determinants were investigated involving bipolar patients classified into two groups-one with favourable course and outcome, and the other with clearly unfavourable prognosis, based on certain recommended criteria, with intermediate prognosis were excluded. As compared to the poor prognosis group, the good prognosis group had… (More)
BACKGROUND Cognitive deficits-the hallmark of schizophrenic deterioration-still remain elusive as far as their pathophysiology is concerned. Various neurotransmitter systems have been implicated to explain these deficits. Abnormalities in cholinergic neurotransmission in the brain are one of the postulations; acetylcholine has also been postulated to… (More)
The natural history of alcoholism was first charted out in 1946 by Jellinek, whose original results have been replicated by multiple research groups. They have verified a general progression of alcohol dependence through a series of identifiable phases. The study investigated the sequence of events in the course of alcohol dependence and its deviations from… (More)