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The ratio of maximum rate of renal tubular reabsorption of phosphate to glomerular filtration rate (TmPO4/GFR) was determined in 546 schoolchildren, aged between 6 and 17.9 years, using the nomogram of Walton and Bijvoet.1 TmPO4/GFR correlated with chronological age in girls and boys and in each remained significantly higher than in adults. TmPO4/GFR in the(More)
Intact parathormone (PTH 1-84) was measured with a new immunoradiometric method in serum from 83 children and adults with various abnormalities of calcium metabolism. The results were compared with those of an assay of midregional PTH fraction (44-68). Both measurements discriminated well between normal controls and patients with primary or secondary(More)
The isoenzymes of serum alkaline phosphatase (AP) were determined in 17 children and 3 adults who had transiently or persistently raised serum AP levels without clinical, laboratory or radiographic evidence of hepatobiliary or bone disease. Liver and bone AP were both raised in 8 of 11 children having transient hyperphosphatasia whereas a rise in only one(More)
Bovine parathyroid extract of E. Lilly (Indianapolis), which has been used to differentiate pseudohypoparathyroidism (PHP) and hypoparathyroidism (HP) is no longer available. We therefore evaluated the usefulness of the synthetic 1–38 fragment of human parathyroid hormone (1–38 hPTH), the biologically active part of the intact hormone, in a simplified(More)
In addition to the well-documented hyporesponsiveness of the kidney, resistance to parathyroid hormone (PTH) has been postulated for bone in pseudohypoparathyroidism type I (PHP). In some of these patients reduced bone density and even frank osteitis fibrosa suggest osteoclastic overactivity. To address the possibility that the skeletal system of patients(More)
OH-P/Cr was measured in morning fasting urine specimens of 300 healthy subjects and of children with disorders of calcium metabolism receiving no diet. In healthy children the values were sex and age dependent reflecting the different height velocities. The OH-P excretion was not different in schoolchildren receiving a OH-P-poor diet for at least two days(More)
The PRL response to the infusion of 8 U/kg BW parathyroid extract (PTE) was studied in three children with pseudohypoparathyroidism type I (PHP), three patients with idiopathic hypoparathyroidism, and eight epileptic children. PTE produced a clear-but increase of serum PRL in the epileptics and patients with idiopathic hypoparathyroidism, but not in the(More)
Direct measurements of parathyroid activity are available in only small numbers of children with vitamin D deficiency rickets (VDR). Therefore serum immunoreactive parathyroid hormone (iPTH) and the urinary cyclic adenosine-3′,5′-monophosphate excretion (UcAMP) were measured together with other important indices of calcium metabolism in 24 patients (aged(More)
In addition to the well-documented hyporesponsiveness of the kidney, resistance to parathyroid hormone (PTH) has been postulated for bone in pseudohypoparathyroidism type I (PHP). In some of these patients reduced bone density and even frank osteitis fibrosa suggest osteoclastic overactivity. To address the possibility that the skeletal system of patients(More)