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Rips (1989) is one of the most widely cited demonstrations of the relevance of critical features in conceptual structure. A critical feature will impose constraints on how an object is classified, regardless of other factors, such as overall similarity. We review and clarify critical features proposals in terms of whether an assumption is being made about(More)
Quantitative information about the innervation is essential to analyze the structure-function relationships of organs. So far, there has been no unbiased stereological tool for this purpose. This study presents a new unbiased and efficient method to quantify the total length of axons in a given reference volume, illustrated on the left ventricle of the(More)
Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia. It is usually caused by a mixture of symptoms of Parkinson's and Alzheimer's disease leading to a significant impairment of nigro-striatal dopaminergic and baso-cortical cholinergic neurotransmission with typical clinical symptoms of a fluctuating course,(More)
Magnetic resonance imaging (MRI) plays an important role in differentiating idiopathic Parkinson's disease (PD) from its atypical forms. Causes like chronic vascular disease and normal-pressure hydrocephalus are easily visualized. Furthermore, specific atrophy patterns can be found with multi-system atrophies, corticobasal degeneration and progressive(More)
Single photon emission computed tomography (SPECT) and positron emission tomography (PET) are important tools in the differential diagnosis and therapeutic monitoring of cognitive disorders. SPECT and PET are highly sensitive methods for the early diagnosis of underlying neurodegeneration and the functional changes in the basal ganglia. Early and reliable(More)
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