Uta Keil

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Transgenic mice overexpressing the P301L mutant human tau protein exhibit an accumulation of hyperphosphorylated tau and develop neurofibrillary tangles. The consequences of tau pathology were investigated here by proteomics followed by functional analysis. Mainly metabolism-related proteins including mitochondrial respiratory chain complex components,(More)
Increasing evidence suggests an important role of mitochondrial dysfunction in the pathogenesis of many common age-related neurodegenerative diseases, including Alzheimer's disease (AD). AD is the most common neurodegenerative disorder characterized by dementia, memory loss, neuronal apoptosis and eventually death of the affected individuals. AD is(More)
Alzheimer's disease is characterized by two major pathological hallmarks: extracellular plaques consisting of amyloid beta peptide and neurofibrillary tangles composed of hyperphosphorylated tau protein. Mutations in the amyloid beta-protein precursor (AbetaPP) have been linked to familial Alzheimer's disease. They are leading to increased amyloid beta(More)
(EEB) or the EC Joint Research Centre (JRC) as well as international organizations like WHO or Health Effects Institute (HEI) provide extensive pooled information on air pollution-related health effects, partially looking at certain air pollutants or specific situations and their impact. Nevertheless, speakers at the current HEI′s Annual meeting in San(More)
Elevated nitric oxide production mediates-amyloid-induced mitochondria failure. Mitochondrial dysfunction has been identified in a large proportion of neurodegen-erative disorders including Alzheimer's disease (AD). In addition, the involvement of ni-tric oxide (NO) has been implicated in the pathogenesis of AD. Thus, we investigated the effects of the(More)
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