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We present a new method for automatic segmentation of heterogeneous image data that takes a step toward bridging the gap between bottom-up affinity-based segmentation methods and top-down generative model based approaches. The main contribution of the paper is a Bayesian formulation for incorporating soft model assignments into the calculation of(More)
Age-related microstructural changes in brain white matter can be studied by utilizing indices derived from diffusion tensor imaging (DTI): apparent diffusion coefficient (ADC) and fractional anisotropy (FA). The objective of this study is to examine alterations in FA and ADC by employing exploratory voxel-based analysis (VBA) and region(s) of interest(More)
PURPOSE To investigate a tetrahedral diffusion gradient encoding scheme to measure the diffusion tensor in vivo for human calf muscle. MATERIALS AND METHODS The theoretical TE which maximizes the signal-to-noise ratio (SNR) of the diffusion images was derived for both the orthogonal and tetrahedral sampling strategies and the SNR advantage verified(More)
We generalize the total variation restoration model, introduced by Rudin, Osher, and Fatemi in 1992, to matrix-valued data, in particular, to diffusion tensor images (DTIs). Our model is a natural extension of the color total variation model proposed by Blomgren and Chan in 1998. We treat the diffusion matrix D implicitly as the product D = LL(T), and work(More)
PURPOSE To create an average atlas of knee femoral cartilage morphology, to apply the atlas for quantitative assessment of osteoarthritis (OA), and to study localized sex differences. MATERIALS AND METHODS High-resolution 3D magnetic resonance imaging (MRI) data of the knee cartilage collected at 3 T as part of the Osteoarthritis Initiative (OAI) were(More)
Diffusion-weighted images based on echo planar sequences suffer from distortions due to field inhomogeneities from susceptibility differences as well as from eddy currents arising from diffusion gradients. In this paper, a novel approach using nonlinear warping based on optic flow to correct distortions of baseline and diffusion weighted echo planar images(More)
Proton phase shift imaging methods with keyholing were developed to rapidly monitor temperature during MR-guided radiofrequency (RF) interventional procedures on a .2-T open configuration scanner. Temperature calibration was performed on thermally controlled gel phantom and ex vivo bovine liver samples. Keyholing methods were implemented for rapid imaging(More)
OBJECTIVE Positron emission tomography (PET), the reference technique for in vivo noninvasive assessment of myocardial perfusion and metabolism, is hampered by limited resolution and low signal-to-noise ratio. Cardiac MR imaging, on the other hand, provides excellent soft-tissue contrast. This study examines the feasibility of combining the information of(More)
The orientation of muscle fibers influences the physiological cross-sectional area, the relationship between fiber shortening and aponeurosis shear, and the total force produced by the muscle. Such architectural parameters are challenging to determine particularly in vivo in multicompartment structures such as the human soleus with a complex arrangement of(More)
This paper describes two schemes for fast diffusion imaging on a 1.5T MRI unit with unshielded gradients and 10-mT/m gradient system. The prepared longitudinal magnetization is sampled by a turbo fast low-angle shot (FLASH) sequence. The first scheme involves modifications to a diffusion-weighted driven-equilibrium preparation sequence that yields(More)