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  • Michael Lawson, Urszula Uciechowska, Jörg Schemies, Tobias Rumpf, Manfred Jung, Wolfgang Sippl
  • Medicine, Biology
  • Biochimica et biophysica acta
  • 2010 (First Publication: 1 October 2010)
  • Histone deacetylases (HDACs) are enzymes that cleave acetyl groups from acetyl-lysine residues in histones and various nonhistone proteins. Unlike the other three of the four classes of HDACs thatExpand
  • Urszula Uciechowska, Jörg Schemies, +4 authors Wolfgang Sippl
  • Chemistry
  • 2012 (First Publication: 1 February 2012)
  • A multi-step virtual screening was carried out in order to identify inhibitors of human NAD+-dependent deacetylase sirtuin 2 (Sirt2). Molecular mechanics Poisson–Boltzmann surface area (MM-PB/SA) andExpand
  • Cecilia Lindgren, I. E. Andersson, +7 authors A. Linusson
  • Medicine, Chemistry
  • Organic & biomolecular chemistry
  • 2015 (First Publication: 27 May 2015)
  • Class II major histocompatibility complex (MHC) proteins are involved in initiation of immune responses to foreign antigens via presentation of peptides to receptors of CD4(+) T-cells. An analogousExpand